Ceftazidime, a potent third-generation cephalosporin antibiotic, plays a crucial role in combating serious bacterial infections. For professionals in the chemical and pharmaceutical industries, understanding its properties is key to effective sourcing and application. This cephalosporin is characterized by its broad spectrum of activity, particularly against Gram-negative bacteria, including the notoriously difficult-to-treat Pseudomonas aeruginosa.

From a chemical perspective, Ceftazidime (CAS 72558-82-8) is a semi-synthetic compound with a molecular formula of C22H22N6O7S2 and a molecular weight of 546.58 g/mol. Its structure features a beta-lactam ring fused to a dihydrothiazine ring, along with a distinctive aminothiazolyl oxime side chain, which contributes to its extended Gram-negative coverage. The compound typically presents as a white to pale yellow crystalline powder and exhibits good solubility in water, a crucial characteristic for its pharmaceutical formulations, often administered via injection.

The mechanism of action for Ceftazidime involves inhibiting bacterial cell wall synthesis by binding to penicillin-binding protein 3 (PBP-3). This disruption leads to bacterial lysis and death. Its clinical applications are widespread, targeting severe infections such as hospital-acquired pneumonia, complicated urinary tract infections, and febrile neutropenia. The demand for high-purity Ceftazidime powder is driven by its essential role in these critical therapeutic areas. Pharmaceutical companies looking to buy Ceftazidime require a consistent supply that adheres to strict purity specifications (typically >99%) to ensure the efficacy and safety of their final medicinal products.

For procurement managers and R&D scientists, identifying a reliable supplier or manufacturer of Ceftazidime API is vital. Sourcing from reputable companies, especially those with GMP certifications, guarantees that the product meets the rigorous quality standards expected in the pharmaceutical industry. When inquiring about Ceftazidime price, it is important to consider the overall value proposition, which includes not only the cost per kilogram but also the supplier's commitment to quality control, regulatory compliance, and supply chain stability. Engaging with suppliers who can provide comprehensive documentation, such as Certificates of Analysis, is essential for due diligence. Whether for formulation development or large-scale production, understanding the chemical and pharmacological profile of Ceftazidime is fundamental for making informed purchasing decisions.