N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt, widely known as Pemetrexed, is a sophisticated molecule with significant implications in modern medicine, particularly in oncology.

Its chemical structure, characterized by a pyrrolopyrimidine antifolate core linked to L-glutamic acid, endows it with potent antimetabolite properties. The molecule's primary mechanism of action involves the inhibition of several key enzymes critical for nucleotide synthesis and folate metabolism: thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). By disrupting these pathways, Pemetrexed effectively halts the proliferation of rapidly dividing cancer cells.

The physical form of Pemetrexed is typically an off-white solid, with a molecular formula of C20H21N5O6 and a molecular weight of 427.41. Its CAS number, 137281-23-3, serves as a unique identifier for this crucial compound. Beyond its established role in treating malignant pleural mesothelioma, Pemetrexed has also been explored for other therapeutic applications, further highlighting its importance in the pharmaceutical landscape.

For researchers and manufacturers, understanding the Pemetrexed chemical properties is fundamental to its successful application. The synthesis of such a complex molecule requires specialized expertise and advanced manufacturing capabilities. Companies that specialize in providing pharmaceutical intermediates supplier China are instrumental in ensuring a consistent and high-quality supply of Pemetrexed.

The therapeutic significance of Pemetrexed is undeniable, but its use also necessitates careful management. Clinical trials have indicated potential side effects, and prophylactic administration of folic acid and vitamin B12 is often recommended to mitigate hematologic and non-hematologic toxicities. This underscores the importance of precise formulation and stringent quality control throughout the chemical synthesis process.

In summary, Pemetrexed represents a vital tool in the fight against cancer. Its complex chemistry and therapeutic power make it a cornerstone for many treatment regimens. Sourcing this compound from reliable manufacturers, particularly from experienced pharmaceutical intermediates supplier China, is essential for advancing medical research and patient care.