The pharmaceutical industry relies heavily on a consistent supply of high-quality intermediates to synthesize life-saving medications. Among these, Terbinafine Hydrochloride stands out as a crucial pharmaceutical intermediate with significant antifungal properties. As a specialized manufacturer and supplier, we are proud to offer Terbinafine Hydrochloride (CAS 78628-80-5) to meet the exacting standards of global pharmaceutical companies.

What is Terbinafine Hydrochloride?

Terbinafine Hydrochloride is an allylamine derivative known for its potent antifungal activity. Its therapeutic value stems from its ability to selectively inhibit fungal squalene epoxidase, a key enzyme in the ergosterol biosynthesis pathway. This inhibition leads to ergosterol deficiency and squalene accumulation within fungal cells, disrupting cell membrane integrity and ultimately leading to fungal death. This targeted mechanism makes it highly effective against a broad spectrum of fungi, including dermatophytes and certain yeasts.

Applications and Therapeutic Importance

The primary applications of Terbinafine Hydrochloride are in the treatment of superficial fungal infections. It is widely used in formulations targeting:

  • Onychomycosis: Infections of the fingernails and toenails.
  • Dermatophytosis: Skin infections such as Tinea pedis (athlete's foot), Tinea cruris (jock itch), and Tinea corporis (ringworm).
  • Cutaneous Candidiasis: Yeast infections affecting the skin.

For researchers and product developers, understanding the properties and applications of this intermediate is key to formulating effective antifungal therapies. The demand for high-purity Terbinafine Hydrochloride continues to grow as the prevalence of fungal infections remains a public health concern.

Procuring Terbinafine Hydrochloride: Supplier Considerations

When looking to buy Terbinafine Hydrochloride, especially for pharmaceutical manufacturing, several factors are crucial for procurement teams:

  1. Purity and Quality: Ensure the supplier provides a Certificate of Analysis (CoA) detailing purity (typically >99%) and compliance with pharmacopoeial standards.
  2. Regulatory Compliance: Look for manufacturers with relevant certifications like ISO and GMP, indicating adherence to international quality standards.
  3. Supply Chain Stability: A manufacturer with a proven track record and significant production capacity (e.g., 20t/Year) can guarantee consistent availability.
  4. Pricing and Quotation: Competitive pricing is essential for cost-effective drug development. Requesting quotes from reputable suppliers is a standard procurement practice.
  5. Technical Support: Access to expert advice and support from the manufacturer can streamline the integration of the intermediate into your processes.

Your Trusted Partner for Pharmaceutical Intermediates

NINGBO INNO PHARMCHEM CO.,LTD. is committed to being a leading supplier of essential pharmaceutical intermediates. We leverage our expertise as a China-based manufacturer to deliver Terbinafine Hydrochloride that meets stringent quality requirements at competitive prices. We invite you to contact us to explore our product offerings, obtain a quotation, and discuss your specific needs. Partner with us for a seamless and reliable supply of this vital antifungal intermediate.