Lumbrokinase, an enzyme found in earthworms, has demonstrated significant potential in various therapeutic applications, particularly concerning cardiovascular health. Clinical studies suggest its efficacy in managing conditions related to blood clots, such as improving circulation and potentially aiding recovery from ischemic events. Research indicates that Lumbrokinase can help break down fibrin, a key component in blood clot formation. Ongoing studies explore its effectiveness and safety profile, especially when used alongside other medications. The growing body of research supports the exploration of natural compounds like Lumbrokinase as complementary therapies for cardiovascular well-being. Further investigation is crucial to fully understand its mechanisms and optimize its therapeutic use.