4-Chloro-2-fluoroanisole, identified by its CAS number 452-09-5, is a valuable organic compound that plays a significant role as an intermediate in various chemical synthesis processes. Its unique molecular structure, C7H6ClFO, with a molecular weight of 160.57, features a benzene ring substituted with a chlorine atom, a fluorine atom, and a methoxy group. This specific arrangement of functional groups dictates its reactivity and utility across different industrial sectors.

Chemically, 4-Chloro-2-fluoroanisole is typically described as a clear to light yellow liquid. Its physical properties include a boiling point around 160°C (at standard pressure) and a density of approximately 1.294 g/mL at 25°C. The presence of both chlorine and fluorine atoms offers distinct sites for nucleophilic or electrophilic substitution reactions, as well as participation in metal-catalyzed cross-coupling reactions, such as Suzuki or Sonogashira couplings. The methoxy group contributes to its overall electronic profile and solubility characteristics.

The applications of 4-Chloro-2-fluoroanisole are diverse, stemming from its role as a versatile building block. In the agrochemical industry, it serves as a key intermediate for synthesizing pesticides and herbicides, contributing to enhanced crop protection. Within the pharmaceutical sector, it is utilized as a precursor for various APIs, particularly those targeting neurological disorders, due to its adaptable structure that can be readily modified to create pharmacologically active molecules.

Furthermore, its unique properties make it relevant in materials science for the development of specialty polymers or liquid crystals. Researchers often seek such functionalized aromatic compounds to impart specific thermal, optical, or electronic properties to new materials. For procurement professionals and researchers, understanding these properties is essential when looking to purchase 4-chloro-2-fluoroanisole or its related derivatives.

As a leading manufacturer and supplier in China, we provide high-purity 4-Chloro-2-fluoroanisole to meet the stringent demands of R&D and industrial production. Whether you are exploring new synthetic pathways or scaling up existing processes, our reliable supply and competitive pricing make us an ideal partner. If you are interested in learning more or need to buy 452-09-5, please contact us for detailed product information and a quote.