In the realm of biochemistry and product formulation, understanding the foundational compounds is key. 2-Ketoglutaric Acid (CAS 328-50-7), often referred to as alpha-ketoglutarate, is a fundamental organic acid that plays a critical role in cellular metabolism. For professionals in the pharmaceutical, food, and health sectors, grasping the scientific principles behind this compound, and sourcing it from a reliable manufacturer, is essential for innovation and quality.

What is 2-Ketoglutaric Acid? The Krebs Cycle Connection
2-Ketoglutaric Acid is a dicarboxylic acid and a keto acid. Its significance is deeply rooted in the Krebs cycle, also known as the citric acid cycle or TCA cycle. This cycle is the primary metabolic pathway for aerobic respiration in all organisms, central to converting carbohydrates, fats, and proteins into ATP, the cell's energy currency. 2-Ketoglutaric acid is a key intermediate formed from the decarboxylation of isocitrate. This position makes it indispensable for the continuation of the cycle and the efficient production of energy within cells. It is typically supplied as a white crystalline powder, with high purity (e.g., 99% min assay) being crucial for its intended applications.

Metabolic Functions and Beyond
Beyond its central role in energy production, 2-ketoglutaric acid is involved in several other vital biological processes:

  • Amino Acid Synthesis: It serves as a precursor for the synthesis of glutamate, an important amino acid and neurotransmitter.
  • Nitrogen Metabolism: It participates in the transamination reactions that link carbohydrate and protein metabolism.
  • Antioxidant Properties: Some research suggests that alpha-ketoglutarate may play a role in mitigating oxidative stress.
  • Wound Healing: Studies have explored its potential to support tissue repair and collagen synthesis.

These diverse functions highlight why 2-ketoglutaric acid is a sought-after ingredient by formulators across different industries.

Sourcing High-Purity 2-Ketoglutaric Acid from a Manufacturer
For businesses requiring this compound, selecting a reputable manufacturer is paramount. We are a dedicated producer of high-purity 2-Ketoglutaric Acid (CAS 328-50-7). Our manufacturing processes are optimized to ensure consistent quality and purity, meeting the stringent requirements of the pharmaceutical, food, and health industries. By choosing to buy directly from a manufacturer, you gain access to competitive pricing and a reliable supply chain. We understand the critical need for dependable raw materials and are committed to being your trusted supplier.

Partner with Us for Your Chemical Needs
We invite researchers, product developers, and procurement managers to explore the quality of our 2-ketoglutaric acid. Whether you need it for pharmaceutical synthesis, food additives, or health supplements, our high-purity product is an ideal choice. Contact us today to request a quote and sample. Leverage our expertise as a manufacturer to secure the essential biochemicals that drive your product innovation and success.