For research and development scientists, a deep understanding of chemical synthesis and properties is fundamental to innovation. 2,4,6-Tri-tert-butylphenol (CAS 732-26-3) is a fascinating molecule whose synthesis and unique properties have been extensively studied. As a sterically hindered phenol, it exhibits remarkable stability and reactivity patterns that make it valuable in various chemical processes. Our role as a chemical manufacturer and supplier is to not only provide this compound but also to offer insights into its chemistry. We are dedicated to supplying researchers and industrial chemists with high-quality 2,4,6-TTBP from our production facilities in China.

Synthesis Routes for 2,4,6-Tri-tert-butylphenol

The preparation of 2,4,6-Tri-tert-butylphenol typically involves the Friedel-Crafts alkylation of phenol with isobutylene. This reaction is usually catalyzed by strong acids, such as sulfuric acid or Lewis acids like aluminum chloride. Early methods described by Wilhelm Koenigs in 1890 involved the direct acid-catalyzed reaction of phenol with isobutylene, achieving significant yields. Modern variations might employ heterogeneous catalysts or different alkylating agents like methyl tert-butyl ether (MTBE) to optimize selectivity and reduce by-product formation, such as mono- and di-alkylated phenols (e.g., 2,6-di-tert-butylphenol).

The reaction conditions, including temperature, pressure, catalyst concentration, and the molar ratio of reactants, are critical for maximizing the yield of the tri-substituted product. For instance, specific molar ratios and temperatures can steer the reaction towards higher selectivity for 2,4,6-TTBP. The reported yields can reach up to 90% under optimized conditions. When you buy 2,4,6-Tri-tert-butylphenol from a reliable manufacturer, you are assured of a product synthesized through well-established and efficient chemical processes.

Key Physicochemical Properties of 2,4,6-TTBP

2,4,6-Tri-tert-butylphenol is characterized by several distinctive properties:

  • Appearance: It typically presents as a white to pale yellow crystalline solid.
  • Solubility: It is insoluble in water but readily dissolves in many common organic solvents like chloroform, DMSO, ethanol, and toluene.
  • Melting Point: Its melting point is generally reported in the range of 125-130 °C, indicating a stable solid form at room temperature.
  • Oxidation Behavior: A notable property is its susceptibility to oxidation. It readily oxidizes to form a stable, deep-blue 2,4,6-tri-tert-butylphenoxy radical. This radical intermediate is key to its function as an antioxidant and is also of significant interest in mechanistic studies.
  • Acidity: As a phenol, it is a weak acid. However, the steric bulk of the tert-butyl groups affects its behavior and interactions.
  • Reactivity: While resistant to many reactions due to steric hindrance, its phenolic hydroxyl group can undergo typical reactions like etherification and esterification under appropriate conditions.

Sourcing and Quality Assurance

For research purposes or as an industrial intermediate, procuring high-quality 2,4,6-Tri-tert-butylphenol is essential. Our role as a chemical supplier from China involves rigorous quality control to ensure that the synthesized product meets specifications, typically with a purity of ≥99%. Researchers looking to buy 2,4,6-TTBP can rely on us for consistent product quality, accurate documentation (including TDS and COA), and competitive pricing. Understanding the synthesis and properties allows scientists to better utilize this versatile chemical.

Regulatory Snapshot

It is crucial for all chemical users to be aware of regulatory updates. 2,4,6-Tri-tert-butylphenol has been designated as an SVHC by the EU REACH due to its environmental and health concerns. While this primarily affects operations within the EU, it highlights the chemical's inherent properties. We remain committed to providing compliant products and transparent information to our global clientele.

We invite chemists and procurement specialists to contact us for inquiries about purchasing 2,4,6-Tri-tert-butylphenol, to obtain a quote, or to request detailed technical specifications.