Pulmonary fibrosis is a serious interstitial lung disease characterized by the progressive scarring of lung tissue, leading to irreversible loss of lung function. While treatments are limited, the exploration of natural compounds with antifibrotic and anti-inflammatory properties offers hope for new therapeutic strategies. Luteolin, a ubiquitous plant flavonoid, has emerged as a promising agent in this area.

Research into luteolin's effects on pulmonary fibrosis suggests it can mitigate lung scarring through several mechanisms. Studies have indicated that luteolin possesses significant anti-inflammatory activity, which is crucial for controlling the inflammatory processes that drive fibrosis. Additionally, luteolin has demonstrated direct antifibrotic effects, including the inhibition of key signaling pathways involved in the differentiation of fibroblasts into myofibroblasts, the cells responsible for producing excess collagen and scar tissue. Specifically, luteolin has been shown to inhibit the TGF-β1 signaling pathway, a master regulator of fibrosis.

Furthermore, luteolin may prevent the epithelial-mesenchymal transition (EMT), a process where lung epithelial cells transform into mesenchymal cells, contributing to fibrosis. By maintaining the integrity of lung epithelial cells, luteolin helps preserve lung function and reduce the progression of scarring.

For companies and researchers focused on developing treatments for pulmonary fibrosis, sourcing high-quality luteolin is a critical first step. NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer and supplier of pharmaceutical intermediates, offering luteolin (CAS 491-70-3) with a high purity of ≥99.0% (HPLC). Our commitment to quality ensures that you receive reliable raw materials for your R&D endeavors. We understand the importance of a consistent supply chain and offer competitive pricing for bulk purchases, making us an ideal luteolin supplier in China.

The antifibrotic and anti-inflammatory properties of luteolin position it as a valuable compound for addressing pulmonary fibrosis. Its potential to inhibit key fibrotic pathways makes it an exciting area for further investigation. If you are looking to buy luteolin cas 491-70-3 for your research into lung health and fibrosis, partner with NINGBO INNO PHARMCHEM CO.,LTD. for premium-grade materials and reliable service.