Lonafarnib, identified by its CAS number 193275-84-2, is a compound of significant scientific interest within the pharmaceutical research community. Its primary function as a farnesyl transferase inhibitor (FTI) places it at the forefront of research into diseases driven by aberrant protein farnesylation. As a leading supplier of specialized pharmaceutical chemicals, we are committed to providing researchers with the high-quality Lonafarnib necessary to explore its diverse applications and unlock new therapeutic avenues.

Understanding Farnesyl Transferase Inhibition

Farnesyl transferase (FTase) is an enzyme critical for the post-translational modification of proteins. It attaches a farnesyl lipid group to specific proteins, including key signaling molecules like Ras. This process is essential for the correct localization and function of these proteins. In many cancers, mutations in Ras proteins lead to uncontrolled cell proliferation and survival. By inhibiting FTase, Lonafarnib disrupts this farnesylation process, thereby interfering with the oncogenic signaling pathways mediated by Ras. This makes Lonafarnib a valuable research tool for investigating targeted cancer therapies.

Applications in Oncology and Beyond

The most prominent application of Lonafarnib in research is its investigation as an anticancer agent. Its ability to block Ras farnesylation offers a direct strategy to counteract oncogenic signaling. Beyond cancer, Lonafarnib has also garnered attention for its potential role in treating rare genetic disorders such as Hutchinson-Gilford Progeria Syndrome (HGPS). In HGPS, a specific farnesylated protein, progerin, accumulates in cells, leading to premature aging phenotypes. Inhibiting FTase with compounds like Lonafarnib has shown potential in mitigating these cellular defects.

Researchers utilize Lonafarnib in various experimental settings:

  • Cell-based assays: To study the effects of FTase inhibition on cell proliferation, apoptosis, and signaling pathways.
  • In vivo studies: As a therapeutic agent in animal models of cancer or progeria to evaluate efficacy and safety.
  • Biochemical analyses: To understand the intricate mechanisms of protein farnesylation and its downstream effects.

Sourcing High-Quality Lonafarnib

For researchers in academic institutions and pharmaceutical companies, sourcing Lonafarnib (CAS 193275-84-2) from a reliable manufacturer is crucial. As a dedicated supplier based in China, we ensure our Lonafarnib is produced under strict quality controls, guaranteeing high purity (≥99%) and consistent batch-to-batch quality. This reliability is essential for reproducible scientific results. We encourage researchers to buy Lonafarnib from trusted sources to ensure the integrity of their experimental data. For those looking for the best price or bulk quantities, inquiring directly with experienced manufacturers is the most effective approach.

The scientific significance of Lonafarnib underscores its importance in modern pharmaceutical research. By providing a dependable source for this critical chemical, we aim to empower scientists in their pursuit of breakthrough discoveries.