For chemists and industrial manufacturers, a deep understanding of a chemical's properties and synthesis is fundamental to its effective application. 3-Amino-4-hydroxybenzoic Acid (CAS 1571-72-8) is no exception. This article explores its key chemical characteristics and provides insights into its synthesis, guiding professionals on how to best utilize and source this important intermediate.

Chemical Profile: Properties of 3-Amino-4-hydroxybenzoic Acid

3-Amino-4-hydroxybenzoic Acid presents as a white to off-white crystalline powder. Key properties that influence its handling and application include:

  • Molecular Formula: C7H7NO3
  • Molecular Weight: 153.14 g/mol
  • Assay: Typically ≥98.0%
  • Melting Point: Approximately 208 °C (with decomposition)
  • Solubility: Soluble in various solvents, facilitating its use in different reaction mediums.
  • Sensitivity: It is noted as being light-sensitive, requiring appropriate storage conditions to maintain its integrity.

These properties dictate how the chemical should be stored (e.g., in a cool, dry place, protected from light) and handled during manufacturing processes. For any manufacturer or supplier, these specifications are critical to communicate to their B2B clientele.

Synthesis Pathways: From Nitrobenzoic Acid to Intermediate

The synthesis of 3-Amino-4-hydroxybenzoic Acid commonly involves the reduction of its nitro precursor, 4-hydroxy-3-nitrobenzoic acid. A typical synthetic route might include:

  1. Reaction Setup: Starting with 4-hydroxy-3-nitrobenzoic acid, reagents like tin(II) chloride and hydrochloric acid are used.
  2. Reduction: The mixture is heated, often to reflux, to facilitate the reduction of the nitro group to an amino group.
  3. Purification: Following the reaction, the product undergoes several purification steps, which may include pH adjustment, filtration, concentration, methanol precipitation, and chromatography to achieve the desired purity.

This process highlights the chemical transformations required to produce high-quality 3-Amino-4-hydroxybenzoic Acid. Understanding the synthesis also helps in appreciating the potential impurities and the importance of rigorous quality control by the manufacturer.

Choosing a Supplier for Your Synthesis Needs

For companies looking to buy 3-Amino-4-hydroxybenzoic Acid, whether for dye production, photosensitive paper manufacturing, or other organic synthesis applications, sourcing from a reliable supplier is key. NINGBO INNO PHARMCHEM CO.,LTD., a prominent manufacturer in China, offers this intermediate with assured quality and competitive pricing. When you purchase this essential chemical, ensure you request detailed product specifications and inquire about bulk purchasing options to secure the best value and ensure a consistent supply for your operations.

By understanding the chemical properties and synthesis of 3-Amino-4-hydroxybenzoic Acid, industrial professionals can make informed decisions to optimize their procurement and manufacturing processes.