In the dynamic field of biochemical and pharmaceutical research, specific chemical compounds serve as invaluable tools for understanding biological pathways and developing potential therapeutics. 4-Diethylaminobenzaldehyde (CAS 120-21-8) has garnered attention for its activity as an Aldehyde Dehydrogenase (ALDH) inhibitor, presenting interesting avenues for scientific exploration. As a leading chemical manufacturer and supplier in China, we provide high-quality research chemicals, including 4-Diethylaminobenzaldehyde, to support your groundbreaking studies.

Understanding Aldehyde Dehydrogenases (ALDHs)

Aldehyde Dehydrogenases (ALDHs) are a superfamily of enzymes crucial for various metabolic processes, including the detoxification of aldehydes. These enzymes play critical roles in cellular redox balance, retinoid metabolism, and the metabolism of xenobiotics. Dysregulation of ALDH activity has been implicated in a range of diseases, including cancer, neurodegenerative disorders, and metabolic syndromes, making ALDHs significant targets for drug development.

4-Diethylaminobenzaldehyde as an ALDH Inhibitor

Research has identified 4-Diethylaminobenzaldehyde as a potent and reversible competitive inhibitor of ALDH1, with a reported Ki value of 4 nM. This high affinity means it can effectively block the enzyme's activity at very low concentrations. Furthermore, it has been shown to irreversibly inactivate ALDH7A1 through the formation of a stable covalent acyl-enzyme species. This differential inhibitory mechanism makes it a valuable probe for studying the specific roles of different ALDH isoforms.

Beyond its ALDH inhibitory properties, studies have also indicated that 4-Diethylaminobenzaldehyde exhibits potent anti-androgenic effects, with an IC50 value of 1.71 μM. This suggests potential applications in research related to hormone-dependent conditions or cancer therapies.

Sourcing for Research Purposes

For researchers and institutions requiring 4-Diethylaminobenzaldehyde, sourcing from a reliable supplier is critical to ensure the integrity and reproducibility of experimental results. Key considerations when purchasing include:

  • Purity and Characterization: Ensure the product meets high purity standards (e.g., ≥99%) and is accompanied by analytical data, such as NMR and HPLC, to confirm its identity and purity.
  • Supplier Reputation: Partner with reputable chemical suppliers or manufacturers known for their commitment to quality and transparency.
  • Research-Specific Packaging: Availability in smaller, research-appropriate quantities is often preferred.
  • Documentation: Access to MSDS and COA is essential for laboratory safety and experimental documentation.

Partnering with a Quality Supplier

As a leading chemical manufacturer in China, we are dedicated to supporting the scientific community by providing high-purity research chemicals. Our 4-Diethylaminobenzaldehyde is produced under stringent quality control measures, ensuring its reliability for biochemical and pharmacological studies. If your research involves studying ALDH pathways, exploring anti-androgenic effects, or utilizing specific organic intermediates, we invite you to request a quote and samples for our 4-Diethylaminobenzaldehyde.

By obtaining your research chemicals from a trusted source, you can confidently advance your scientific investigations and contribute to new discoveries.