For formulators working in the cosmetic and chemical industries, a thorough understanding of the properties of their raw materials is fundamental to creating effective and stable products. 2-Amino-5-ethylphenol Hydrochloride (CAS: 149861-22-3) is one such ingredient whose chemical characteristics dictate its application, particularly in hair dye formulations. This article explores these properties from a formulator's perspective.

Physical and Chemical Characteristics

2-Amino-5-ethylphenol Hydrochloride typically presents as a beige to brown powder. Its molecular formula is C8H12ClNO, with a molecular weight of approximately 173.64 g/mol. The presence of the hydrochloride salt form influences its solubility and handling characteristics. Key physical properties include a melting point with decomposition above 163°C, a boiling point around 290°C, and a flash point of 129.2°C. For formulators, understanding its solubility is crucial; it's reported to be highly soluble in water (428 g/L at 20 °C) and also soluble in solvents like DMSO and methanol, which is advantageous for incorporation into aqueous or solvent-based systems.

Reactivity and Functional Groups

The chemical reactivity of 2-Amino-5-ethylphenol Hydrochloride stems from its key functional groups:

  • Amino Group (-NH2): This primary amine is nucleophilic and basic, allowing it to undergo a variety of reactions, including salt formation, acylation, and importantly, oxidation. In oxidative hair dyes, this group is oxidized to form chromophores.
  • Hydroxyl Group (-OH): The phenolic hydroxyl group is weakly acidic and can participate in etherification, esterification, and coupling reactions. It also contributes to the compound's solubility and potential for hydrogen bonding.
  • Aromatic Ring: The benzene ring provides a stable scaffold and is susceptible to electrophilic aromatic substitution, allowing for further modification of the molecule's properties.

Applications Driven by Properties

These chemical properties make 2-Amino-5-ethylphenol Hydrochloride ideal for its primary role as a precursor in oxidative hair dyes. When mixed with oxidizing agents and couplers, it forms complex color molecules that penetrate the hair shaft. Its solubility ensures it can be easily dispersed in typical dye formulations. For formulators seeking to buy 2-Amino-5-ethylphenol Hydrochloride, ensuring the supplier provides detailed specifications, including purity (≥99.0% via HPLC), helps predict its performance in formulation.

Sourcing and Quality Assurance

As a formulator, securing a reliable supply of high-quality 2-Amino-5-ethylphenol Hydrochloride is critical. Partnering with a reputable manufacturer or supplier, such as NINGBO INNO PHARMCHEM CO.,LTD., is essential. They provide not only the material but also the necessary documentation like Certificates of Analysis (CoA) and Safety Data Sheets (SDS). When you purchase from them, you are assured of material that meets industry standards.

Conclusion

The chemical properties of 2-Amino-5-ethylphenol Hydrochloride are intrinsically linked to its effectiveness as a hair dye intermediate. Understanding these characteristics allows formulators to optimize their product development, ensuring vibrant color, formulation stability, and product safety. By sourcing this compound from trusted manufacturers, formulators can confidently incorporate it into their innovative cosmetic solutions.