For chemists and product developers, understanding the underlying chemistry of key intermediates is fundamental to unlocking their full potential. This article explores the synthesis, properties, and reactivity of 2-Methyl-5-nitrophenol (CAS 5428-54-6), a crucial compound in various chemical industries.

Chemical Identity and Properties
2-Methyl-5-nitrophenol, also known as 5-Nitro-o-cresol, is an organic compound characterized by its phenolic structure, a methyl group at the second position, and a nitro group at the fifth position on the benzene ring. Its molecular formula is C7H7NO3, with a molecular weight of 153.14 g/mol. Typically appearing as a light yellow to brown powder, it exhibits a melting point of 111-115°C and is slightly soluble in organic solvents like methanol and chloroform.

Synthesis Pathways for 2-Methyl-5-nitrophenol
The production of 2-Methyl-5-nitrophenol commonly involves the electrophilic nitration of o-cresol using a mixture of nitric and sulfuric acids. This process requires precise control over reaction parameters such as temperature, acid concentration, and reaction time to maximize yield and achieve the desired regioselectivity. Alternative synthesis routes, such as those involving the diazotization and hydrolysis of 2-methyl-5-nitroaniline, are also employed.

Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., a prominent 2-Methyl-5-nitrophenol manufacturer in China, utilize optimized synthesis protocols to ensure high purity and consistent quality. When you seek to buy 2-Methyl-5-nitrophenol, engaging with a reputable 2-Methyl-5-nitrophenol supplier like us guarantees access to a well-characterized product suitable for demanding applications.

Reactivity and Applications
The presence of the electron-withdrawing nitro group and the electron-donating hydroxyl and methyl groups influences the reactivity of the aromatic ring. This makes 2-Methyl-5-nitrophenol a versatile intermediate for further chemical transformations. Its most notable application is in the synthesis of pyranocarbazole alkaloids, which are of interest in pharmaceutical research. It also serves as a key intermediate in the production of dyes, pigments, and hair dyes, highlighting its significance in both the chemical and cosmetic industries.

Procurement and Quality Assurance
For R&D scientists and procurement managers, securing a reliable source for such intermediates is critical. We offer high-purity 2-Methyl-5-nitrophenol at competitive prices, backed by robust quality control measures. As a leading 2-Methyl-5-nitrophenol supplier, our focus is on enabling your research and manufacturing success through consistent product quality and dependable service.

To source this essential intermediate for your projects, consider the expertise and reliability of NINGBO INNO PHARMCHEM CO.,LTD. Contact us for quotes and detailed product information.