2,4,6-Trichlorophenylhydrazine (CAS 5329-12-4) is a fascinating organic compound that plays a significant role as a chemical intermediate. As a prominent manufacturer and supplier of this chemical from China, we find it important to share a technical overview of its properties, reactivity, and how these attributes make it valuable for industries like pharmaceuticals and dyes. For professionals looking to buy this compound, a deeper chemical understanding is always beneficial.

Molecular Structure and Properties: The chemical name, 2,4,6-Trichlorophenylhydrazine, precisely describes its structure: a phenylhydrazine molecule where chlorine atoms are substituted at the ortho (2 and 6) and para (4) positions on the benzene ring. Its molecular formula is C6H5Cl3N2, and it has a molecular weight of approximately 211.48 g/mol. The presence of three electron-withdrawing chlorine atoms significantly influences the electronic distribution within the molecule. This often results in increased acidity of the N-H protons compared to unsubstituted phenylhydrazine and can also impact its reactivity in electrophilic aromatic substitution reactions. The compound is typically described as a white crystalline solid, with a melting point usually in the range of 140-147°C. As a high-purity manufacturer, we ensure our product adheres to these specifications, with an assay typically ≥99%.

Reactivity and Synthesis Applications: The hydrazine functional group (-NHNH2) is a nucleophilic center and a potent reducing agent, making 2,4,6-Trichlorophenylhydrazine a versatile reagent in organic synthesis. Key reactions include:

  • Condensation Reactions: It readily reacts with aldehydes and ketones to form hydrazones, which are often intermediates in further transformations, such as the Fischer indole synthesis.
  • Azo Coupling: The compound can be diazotized and then coupled with activated aromatic compounds to form azo dyes. The chlorine substituents can influence the chromophore's stability and color properties.
  • Nucleophilic Substitution: The hydrazine moiety can act as a nucleophile in various reactions.

These reactions are fundamental when pharmaceutical researchers or dye chemists decide to buy 2,4,6-Trichlorophenylhydrazine for their specific applications. The precise placement of chlorine atoms can impart unique characteristics to the final products, such as enhanced light fastness in dyes or specific binding affinities in drug molecules.

Sourcing High-Quality Intermediate: When procuring 2,4,6-Trichlorophenylhydrazine, selecting a reliable supplier is critical. A well-established manufacturer will provide detailed technical data, including spectroscopic information if available, and ensure lot-to-lot consistency. We pride ourselves on offering a product that meets the exacting standards required by our clients, backed by competitive pricing and responsive customer service. If your work demands this specific intermediate, partnering with a knowledgeable Chinese manufacturer like us ensures you obtain a high-purity product for your synthetic needs.

By understanding the chemical properties and reactivity of 2,4,6-Trichlorophenylhydrazine, professionals can better leverage its potential in their diverse synthetic endeavors.