In the intricate field of organic synthesis, the selection of appropriate building blocks is fundamental to achieving desired molecular structures and functions. 2-Amino-3-nitrophenol, with its CAS number 603-85-0, stands out as a versatile and valuable intermediate, offering chemists a unique combination of functional groups for diverse synthetic applications. This article explores the utility of 2-Amino-3-nitrophenol in organic synthesis and provides guidance for R&D professionals and purchasing managers on how to source this essential chemical from quality manufacturers.

The Chemical Versatility of 2-Amino-3-nitrophenol

2-Amino-3-nitrophenol is an aromatic compound characterized by its distinctive brown-red crystalline powder form and typically high purity, often 99% or more. Its molecular structure (C6H6N2O3) features an amino group (-NH2), a nitro group (-NO2), and a phenolic hydroxyl group (-OH). These functional groups impart significant reactivity and versatility, making it a sought-after intermediate in several chemical transformations:

  • Functional Group Reactivity: The amine group can undergo diazotization, acylation, and alkylation. The nitro group can be reduced to an amine, and the hydroxyl group can be etherified or esterified. This allows for a wide range of derivatization reactions.
  • Cyclization Reactions: The proximity of the amino and hydroxyl groups, along with the nitro substituent, facilitates participation in cyclization reactions, leading to the formation of heterocyclic compounds, which are common motifs in pharmaceuticals and agrochemicals.
  • Building Block for Complex Molecules: It serves as a foundational component for synthesizing more complex organic molecules, where precise structural elements are required.

Applications in Research and Development

Beyond its established role in the dye industry, 2-Amino-3-nitrophenol is frequently utilized in:

  • Pharmaceutical Synthesis: As an intermediate, it can be a starting point for synthesizing active pharmaceutical ingredients (APIs) or their precursors.
  • Agrochemical Development: Its structure is relevant in the synthesis of certain crop protection agents.
  • Materials Science: Researchers may explore its use in the development of novel organic materials with specific electronic or optical properties.

Strategic Sourcing: Finding the Right Manufacturer

For R&D scientists and procurement specialists, sourcing high-quality 2-Amino-3-nitrophenol (CAS 603-85-0) is key to successful synthesis projects. When looking to buy this intermediate:

  • Prioritize Purity: Always confirm the minimum purity level, ideally 99% or higher, and request documentation such as a Certificate of Analysis (CoA).
  • Evaluate Supplier Reliability: Look for established chemical manufacturers with a strong reputation for quality and consistency. China is a major source for many organic intermediates.
  • Compare Pricing and Lead Times: Obtaining multiple quotes from different suppliers will help secure competitive pricing and understand delivery timelines.
  • Check Packaging Options: Suppliers often offer various packaging sizes, from grams for laboratory use to bulk quantities for industrial applications.

Conclusion: Partnering for Synthesis Success

2-Amino-3-nitrophenol (CAS 603-85-0) is more than just a chemical compound; it is a critical tool for innovation in organic synthesis. By understanding its chemical versatility and strategically sourcing it from reputable manufacturers, particularly those based in China known for their production capabilities, R&D teams can ensure their projects are well-equipped for success. If you are seeking to buy this essential intermediate, engaging with experienced chemical suppliers will be your first step toward efficient and effective synthesis.