Organic synthesis is the backbone of many industries, from pharmaceuticals to advanced materials. At the heart of this field are chemical intermediates, compounds that serve as building blocks for more complex molecules. One such versatile intermediate is 2-Chloro-5-nitrobenzonitrile (CAS 16588-02-6). This article delves into its significance in organic synthesis and guides procurement professionals and research scientists on where to source it effectively.

Chemical Properties and Significance

2-Chloro-5-nitrobenzonitrile, identified by its CAS number 16588-02-6, is a fine chemical characterized by its light yellow crystalline powder form. With the molecular formula C7H3ClN2O2, it possesses a unique structure featuring a nitrile group, a nitro group, and a chlorine atom attached to a benzene ring. This specific arrangement of functional groups makes it a valuable synthon for a variety of chemical transformations.

Its applications extend beyond its well-known role as a dyestuff intermediate. In organic synthesis, the reactive nitrile group can undergo hydrolysis to form carboxylic acids, reduction to amines, or participate in cycloaddition reactions. The nitro group can be reduced to an amine, which is a precursor for many heterocyclic compounds and dyes. The chlorine atom can be displaced in nucleophilic aromatic substitution reactions, allowing for the introduction of various other functional groups. This versatility makes 2-chloro-5-nitrobenzonitrile a sought-after chemical for researchers and industrial chemists.

Applications in Research and Industry

While its primary industrial application is in the synthesis of dyes, the potential for 2-chloro-5-nitrobenzonitrile in broader organic synthesis is significant. Researchers often utilize such intermediates in the development of novel compounds for pharmaceutical, agrochemical, and material science applications. The ability to modify its structure through well-established chemical reactions allows for the creation of diverse molecular architectures.

For companies involved in custom synthesis or specialized chemical manufacturing, having a reliable source for intermediates like 2-chloro-5-nitrobenzonitrile is crucial. It enables them to efficiently develop and produce target molecules, meeting the demands of their respective markets. When looking to buy this chemical, focus on suppliers who can guarantee high purity, typically 97% or 99% minimum assay, as this is vital for successful reaction outcomes and the purity of the final product.

Sourcing Strategies for Chemists and Buyers

When procuring 2-chloro-5-nitrobenzonitrile, it is recommended to partner with manufacturers who offer direct sales and have a strong presence in the market. Sourcing from established chemical suppliers, particularly those based in China, can offer advantages in terms of cost-effectiveness and availability. Prioritize suppliers who provide comprehensive technical data, safety data sheets (SDS), and certificates of analysis (CoA) to ensure product quality and safe handling. Exploring options for online purchase or requesting quotes from multiple manufacturers will help you secure the best value and ensure a consistent supply chain for your synthetic chemistry needs.

In summary, 2-Chloro-5-nitrobenzonitrile is a valuable intermediate in organic synthesis due to its versatile reactivity. By understanding its applications and adopting a strategic sourcing approach, researchers and industrial chemists can effectively procure this compound to drive innovation and production.