2-Bromoaniline (CAS 615-36-1) is a chemical compound of significant industrial importance, primarily serving as a key intermediate in the synthesis of dyes and pharmaceuticals. Understanding its synthesis pathways and its broader industrial role provides insight into its value in the chemical market.

Several methods can be employed for the synthesis of 2-Bromoaniline. One common approach involves the bromination of aniline under specific conditions to favor ortho-substitution, or indirect methods involving nitrobenzene derivatives. A typical route might start with aniline, which is first protected, then brominated, and finally deprotected. Alternatively, nitration of bromobenzene followed by reduction of the nitro group can yield bromoanilines, with separation techniques used to isolate the ortho isomer.

A more detailed industrial synthesis might involve the reaction of 2-nitroaniline. This starting material is diazotized using sodium nitrite in sulfuric acid to form a diazonium salt. This salt is then reacted with hydrobromic acid in the presence of a copper bromide catalyst, leading to the formation of 2-bromonitrobenzene. Subsequent reduction, often using iron powder in acidic conditions, converts the nitro group to an amine, yielding 2-Bromoaniline. Each step requires precise control of temperature, concentration, and reaction time to maximize yield and purity.

The industrial significance of 2-Bromoaniline is multifaceted. Its primary use as a dye raw material, especially for azo dyes, is well-established. The structural features of 2-Bromoaniline allow for the creation of dyes with specific colors and functional properties, catering to the demands of the textile and printing industries. Moreover, its role as a pharmaceutical intermediate is critical. It serves as a building block in the synthesis of various APIs, contributing to the development of drugs that treat a range of conditions. This dual application ensures a consistent demand for high-quality 2-Bromoaniline.

For manufacturers, sourcing 2-Bromoaniline with a high assay (≥99%) is essential for ensuring the quality and efficiency of their production processes. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are instrumental in providing this intermediate, ensuring adherence to strict quality standards. The reliability of supply and the consistent properties of the chemical are key factors for downstream users.

The market for 2-Bromoaniline is influenced by the health of the industries it serves. Growth in textiles, printing, and pharmaceuticals directly translates to increased demand for this vital chemical intermediate. As chemical manufacturing technologies advance, more efficient and environmentally friendly synthesis routes for 2-Bromoaniline may emerge, further solidifying its position in the market.

In summary, the synthesis of 2-Bromoaniline, while involving multiple chemical steps, is well-established for industrial production. Its significance as a dye raw material and a pharmaceutical intermediate underscores its indispensable role in the global chemical supply chain.