For chemists and researchers in the field of organic synthesis, a thorough understanding of key intermediates is paramount. 5-Bromopyrimidine, identified by its CAS number 4595-59-9, is one such compound that warrants close examination due to its wide-ranging utility. This article provides an in-depth look at its chemical and physical properties, common synthesis methods, and its significant applications across various scientific disciplines.

Physically, 5-Bromopyrimidine typically presents as a yellow to beige-brown crystalline powder. It possesses a melting point around 69°C and is characterized by a density of approximately 1.64 g/cm³. While sparingly soluble in water, it readily dissolves in common organic solvents such as chloroform, making it amenable to a variety of reaction conditions. The molecular formula C4H3BrN2 and a molecular weight of 158.98 further define its chemical identity. These properties are critical for chemists when planning synthetic strategies and ensuring optimal reaction yields. NINGBO INNO PHARMCHEM CO.,LTD. ensures that the 5-Bromopyrimidine they supply meets these critical specifications, allowing researchers to buy with confidence.

The synthesis of 5-Bromopyrimidine can be achieved through several methods, often involving the reaction of a furan derivative with formamide under specific conditions. One common route involves the reaction of dibromodifuranone with formamide in the presence of a catalyst at elevated temperatures. The efficiency and yield of these synthetic routes are crucial for its commercial availability. As a prominent manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. focuses on optimizing these production processes to guarantee a stable and high-quality supply of 5-Bromopyrimidine. This commitment to efficient synthesis ensures that the compound remains accessible for widespread use.

The applications of 5-Bromopyrimidine are extensive, spanning from pharmaceutical synthesis to agrochemical development. It serves as a crucial intermediate in the creation of Flurprimidol, a plant growth regulator. Moreover, its role in palladium-catalyzed reactions, like Suzuki and Sonogashira couplings, makes it a valuable building block for constructing complex heterocyclic systems used in medicinal chemistry and materials science. Researchers often seek to buy 5-Bromopyrimidine to explore novel chemical pathways and develop new compounds with desirable properties. Partnering with a reliable supplier like NINGBO INNO PHARMCHEM CO.,LTD. is key to accessing this versatile chemical for your research needs.