4-Chlorophthalic Anhydride (CAS 118-45-6) is a chemical compound of significant industrial importance, primarily due to its versatile reactivity and utility as a synthetic intermediate. Understanding its chemical properties and synthesis pathways is key to appreciating its broad applications. NINGBO INNO PHARMCHEM CO.,LTD. sheds light on these fundamental aspects.

The molecular formula of 4-Chlorophthalic Anhydride is C8H3ClO3, with a molecular weight of 182.56. Its most striking characteristic is the presence of a chlorine atom at the 4-position of the phthalic anhydride structure. This electron-withdrawing group activates the aromatic ring, enhancing its susceptibility to nucleophilic attack and facilitating a range of chemical transformations. The compound typically presents as a white to almost white crystalline powder, with a melting point around 96°C, indicating a solid state at room temperature.

Key chemical properties that make 4-Chlorophthalic Anhydride valuable include:

Reactivity: Its anhydride functionality readily reacts with nucleophiles, such as alcohols and amines, to form esters and amides, respectively. The activated aromatic ring also undergoes electrophilic substitution reactions, although less readily due to the deactivating effect of the anhydride group. This dual reactivity makes it a versatile building block.

Solubility: 4-Chlorophthalic Anhydride is soluble in various organic solvents like toluene, acetone, and chloroform, which is crucial for its use in solution-phase synthesis. It is generally insoluble in water, which can be advantageous for certain separation processes.

Thermal Stability: While specific decomposition temperatures vary, it possesses reasonable thermal stability for typical synthetic conditions.

Regarding its synthesis, common methods often involve the chlorination of phthalic anhydride or phthalic acid. One prominent route is the selective chlorination of phthalic anhydride using chlorine gas in the presence of a catalyst. Careful control of reaction conditions is essential to ensure regioselectivity and minimize the formation of unwanted isomers or by-products. Alternative methods may involve direct chlorination of phthalic acid followed by dehydration to form the anhydride. NINGBO INNO PHARMCHEM CO.,LTD. employs optimized synthetic processes to ensure high purity and yield for its customers.

The market for 4-Chlorophthalic Anhydride is influenced by its diverse applications, particularly in the pharmaceutical and polymer industries. As a trusted supplier in China, we are committed to providing materials that meet the precise requirements of these sectors. Our expertise in chemical synthesis ensures that we can offer a reliable source of high-quality 4-Chlorophthalic Anhydride, supporting the innovation and production needs of our global clientele.