Understanding the Chemical Properties of Methyl 1-bromo-2-naphthoate
Methyl 1-bromo-2-naphthoate, with the CAS Registry Number 89555-39-5, is a significant chemical intermediate utilized in various organic synthesis applications. Understanding its fundamental chemical properties is crucial for chemists aiming to effectively employ it in their research and manufacturing processes. This compound, often supplied as a white powder, possesses a molecular formula of C12H9BrO2 and a molecular weight of approximately 265.10 g/mol. Its physical characteristics, such as a reported melting point of around 60°C and a boiling point of approximately 350.7°C at standard pressure, provide essential data for handling and reaction design.
The reactivity of Methyl 1-bromo-2-naphthoate is largely dictated by the presence of the bromine atom and the methyl ester group on the naphthalene core. The bromine substituent is positioned on the naphthoic acid derivative, making it an amenable site for nucleophilic substitution and, more importantly, for participation in transition-metal-catalyzed cross-coupling reactions. These reactions are foundational in modern organic synthesis for forming new carbon-carbon bonds, which are essential for building complex molecular structures required in fields like OLED materials and pharmaceutical intermediates.
The ester functional group also offers a point of chemical manipulation. It can undergo hydrolysis to yield the corresponding carboxylic acid, be reduced to an alcohol, or converted into amides through aminolysis. This versatility allows chemists to introduce a variety of other functional groups or link the naphthalene moiety to different molecular fragments, thereby tailoring the properties of the final product. For instance, in the synthesis of OLED intermediates, these transformations are vital for achieving the specific electronic and optical characteristics needed for efficient device performance.
When sourcing Methyl 1-bromo-2-naphthoate, chemists often look for high purity (e.g., 97% or 99% minimum) to ensure optimal reaction outcomes and product quality. Manufacturers in China are key suppliers of this intermediate, providing crucial materials for global research and development efforts. By understanding these chemical properties, researchers can better select appropriate reaction conditions, anticipate potential side reactions, and confidently integrate Methyl 1-bromo-2-naphthoate into their synthetic strategies, contributing to advancements in electronic materials and beyond.
The reactivity of Methyl 1-bromo-2-naphthoate is largely dictated by the presence of the bromine atom and the methyl ester group on the naphthalene core. The bromine substituent is positioned on the naphthoic acid derivative, making it an amenable site for nucleophilic substitution and, more importantly, for participation in transition-metal-catalyzed cross-coupling reactions. These reactions are foundational in modern organic synthesis for forming new carbon-carbon bonds, which are essential for building complex molecular structures required in fields like OLED materials and pharmaceutical intermediates.
The ester functional group also offers a point of chemical manipulation. It can undergo hydrolysis to yield the corresponding carboxylic acid, be reduced to an alcohol, or converted into amides through aminolysis. This versatility allows chemists to introduce a variety of other functional groups or link the naphthalene moiety to different molecular fragments, thereby tailoring the properties of the final product. For instance, in the synthesis of OLED intermediates, these transformations are vital for achieving the specific electronic and optical characteristics needed for efficient device performance.
When sourcing Methyl 1-bromo-2-naphthoate, chemists often look for high purity (e.g., 97% or 99% minimum) to ensure optimal reaction outcomes and product quality. Manufacturers in China are key suppliers of this intermediate, providing crucial materials for global research and development efforts. By understanding these chemical properties, researchers can better select appropriate reaction conditions, anticipate potential side reactions, and confidently integrate Methyl 1-bromo-2-naphthoate into their synthetic strategies, contributing to advancements in electronic materials and beyond.
Perspectives & Insights
Silicon Analyst 88
“By understanding these chemical properties, researchers can better select appropriate reaction conditions, anticipate potential side reactions, and confidently integrate Methyl 1-bromo-2-naphthoate into their synthetic strategies, contributing to advancements in electronic materials and beyond.”
Quantum Seeker Pro
“Methyl 1-bromo-2-naphthoate, with the CAS Registry Number 89555-39-5, is a significant chemical intermediate utilized in various organic synthesis applications.”
Bio Reader 7
“Understanding its fundamental chemical properties is crucial for chemists aiming to effectively employ it in their research and manufacturing processes.”