4-Fluorobenzoic acid, a compound with the CAS number 456-22-4 and molecular formula C7H5FO2, is a significant organic intermediate with a diverse range of applications across multiple industries. This article aims to provide a comprehensive overview of its key chemical and physical properties, its critical uses, and insights into its manufacturing and supply, particularly from China.

Chemically, 4-Fluorobenzoic acid is a derivative of benzoic acid, distinguished by a fluorine atom substituted at the para position of the benzene ring. This structural feature significantly influences its reactivity and the properties of compounds derived from it. Key physical properties include its appearance as a white to yellow powder, a melting point typically in the range of 182-184°C, and a boiling point of approximately 253.7°C. It exhibits good solubility in organic solvents like alcohol and methanol, and slight solubility in water, which aids in its application in various synthesis processes. Its purity, often specified at ≥99.0% via HPLC, and low moisture content (≤0.5%) underscore its suitability for high-precision chemical work.

The applications of 4-Fluorobenzoic acid are widespread and impactful. Primarily, it serves as a crucial intermediate in organic synthesis, acting as a foundational molecule for creating more complex compounds. In the pharmaceutical industry, it is vital for synthesizing active pharmaceutical ingredients (APIs), where the fluorine substituent can enhance drug efficacy, metabolic stability, and bioavailability. For example, it's used to synthesize radiolabeled tracers for medical imaging. The agrochemical sector also benefits from its properties, utilizing it in the production of pesticides and herbicides to improve their bioactivity and persistence. Furthermore, it finds applications in materials science for developing specialty polymers and in various research fields for detailed chemical studies.

China has emerged as a global hub for the production of fine chemicals, and 4-Fluorobenzoic acid is no exception. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. employ advanced synthesis techniques to ensure high yields and purity, making them leading suppliers. The competitive price of 4-Fluorobenzoic acid from these suppliers makes it an attractive option for businesses worldwide. When looking to buy 4-Fluorobenzoic acid, understanding the specifications, particularly purity and consistency, is essential for successful application. Sourcing from reputable manufacturers in China guarantees access to a reliable supply of this critical chemical intermediate, supporting innovation across research and industry.