N1-(3-Aminophenyl)acetamide (CAS 102-28-3), also known as 3-Aminoacetanilide, is a valuable organic intermediate with a chemical structure that lends itself to a variety of synthetic applications. Understanding its common synthesis routes and its functional uses is crucial for R&D scientists and procurement specialists looking to leverage this compound. This article explores the typical preparation methods and primary applications of N1-(3-Aminophenyl)acetamide, while also guiding potential buyers on how to buy N1-(3-Aminophenyl)acetamide effectively from China-based manufacturers.

Synthesis of N1-(3-Aminophenyl)acetamide

The most common industrial synthesis of N1-(3-Aminophenyl)acetamide involves the reduction of its nitro precursor, 3'-nitroacetanilide. A typical synthesis route might include:

  • Reduction of 3'-Nitroacetanilide: 3'-Nitroacetanilide is treated with a reducing agent to convert the nitro group (-NO2) into an amine group (-NH2). Common reducing agents employed in industrial settings include catalytic hydrogenation (using catalysts like Palladium on carbon) or chemical reduction using agents such as iron or tin in acidic conditions, or sodium hydrosulfite.
  • Purification: Following the reduction, the crude product is purified through techniques like recrystallization or column chromatography to achieve the desired purity levels, often yielding a white to off-white crystalline solid.

The efficiency and yield of these synthesis routes are critical for ensuring cost-effective production. For businesses looking to purchase N1-(3-Aminophenyl)acetamide, working with a manufacturer that has optimized these synthesis steps is advantageous.

Key Applications of N1-(3-Aminophenyl)acetamide

N1-(3-Aminophenyl)acetamide's bifunctional nature makes it a versatile intermediate in several chemical sectors:

  • Dye Intermediates: Its amine group can be readily diazotized and coupled with various components to form azo dyes. These dyes are used extensively in the textile, leather, and paper industries for their broad spectrum of colors and good fastness properties.
  • Electronic Chemicals: It serves as a precursor in the synthesis of specialized chemicals used in the electronics industry, particularly in the formulation of photoresist materials for lithography. The amine functionality can be modified to create specific sensitizers or polymers.
  • Pharmaceutical Intermediates: While less common, its structure can be a starting point for certain pharmaceutical compounds, though its primary commercial use is in dyes and electronic chemicals.
  • Organic Synthesis: As a general organic building block, it can be used in various research and development projects for synthesizing novel compounds with specific properties.

Procurement Strategies

When sourcing N1-(3-Aminophenyl)acetamide (CAS 102-28-3), it is advisable to partner with established N1-(3-Aminophenyl)acetamide suppliers, particularly those based in China, which is a major global producer. Key aspects to consider when making a purchase include:

  • Supplier Reputation: Choose manufacturers with a strong track record in producing high-purity fine chemicals.
  • Quality Documentation: Always request a Certificate of Analysis (CoA) to verify purity and other specifications.
  • Pricing and Lead Times: Obtain quotes from multiple suppliers to compare pricing and delivery schedules, especially for bulk orders.

By understanding the synthesis and applications of N1-(3-Aminophenyl)acetamide and adopting a strategic sourcing approach, businesses can ensure a reliable supply of this important intermediate for their manufacturing and R&D needs.