Sieber Linker, a compound identified by CAS number 3722-51-8, is a critical chemical reagent with diverse applications, primarily in peptide synthesis and drug discovery. Understanding its fundamental properties, synthesis pathways, and market dynamics is essential for researchers and industry professionals. This overview provides insights into the chemistry of Sieber Linker and its place within the broader chemical market.

Chemically, Sieber Linker is known as 3-Hydroxyxanthen-9-one. It typically presents as a white to off-white powder, with purity levels often exceeding 98% or 99% as determined by HPLC analysis. Its molecular formula is C13H8O3, and it has a molecular weight of approximately 212.20 g/mol. The compound's melting point is typically reported in the range of 250-262 °C, indicating its solid state at room temperature. Its solubility in common organic solvents like chloroform, dichloromethane, ethyl acetate, DMSO, and acetone makes it amenable to various synthetic procedures.

The synthesis of Sieber Linker often involves reactions utilizing starting materials such as salicylic acid and resorcinol, or other related phenolic compounds. While specific synthesis protocols can vary among manufacturers, the goal is consistently to achieve high purity and yield. Research into more efficient and environmentally friendly synthesis methods is ongoing, driven by the increasing demand for this linker in various scientific applications. Understanding the synthesis pathways helps in appreciating the quality and consistency of the product obtained from different suppliers.

The market for Sieber Linker is influenced by the growth in peptide-based therapeutics, diagnostics, and advanced materials. As peptide drugs continue to gain traction for treating various diseases, the demand for essential components like linkers remains robust. The growing field of chemical biology, which uses linkers for complex molecular construction and interaction studies, further contributes to market expansion. Procurement specialists observe competitive pricing from various global suppliers, with price points often varying based on purity, quantity, and supplier. Analyzing market trends reveals a steady demand, with key suppliers located in China, the United States, and Europe, each offering different advantages in terms of service and pricing for Sieber Linker procurement.

For professionals seeking this reagent, it is crucial to engage with suppliers who can provide comprehensive documentation, including COAs and SDS, to ensure product quality and safety. The increasing complexity of research necessitates reliable access to high-quality chemical building blocks, making Sieber Linker a vital component in the toolkit of modern chemists and biologists.