Understanding the fundamental chemical properties and synthesis routes of key industrial compounds is central to innovation at NINGBO INNO PHARMCHEM CO.,LTD. Ethyl 3-Methyl-3-Phenylglycidate (CAS 77-83-8), renowned for its strawberry-like aroma, also possesses a chemical structure that lends itself to diverse synthetic pathways and industrial applications.

Chemically, Ethyl 3-Methyl-3-Phenylglycidate is an ester derived from glycidic acid. Its molecular formula is C12H14O3, with a molecular weight of approximately 206.24 g/mol. It is characterized by the presence of an epoxide ring and an ester functional group, along with phenyl and methyl substituents. This combination of functional groups makes it a moderately reactive compound, susceptible to hydrolysis under strongly acidic or alkaline conditions. Its physical form is typically a colorless to pale yellow liquid, with a characteristic sweet, fruity odor often described as strawberry-like. Key physical properties include a boiling point of around 272-275 °C and a density of approximately 1.087 g/mL at 25 °C.

The synthesis of Ethyl 3-Methyl-3-Phenylglycidate commonly involves the Darzens condensation reaction. This classic organic reaction typically pairs an alpha-halo ester with a ketone or aldehyde in the presence of a strong base. For Ethyl 3-Methyl-3-Phenylglycidate, this usually involves the reaction between acetophenone and ethyl chloroacetate. The base used, such as sodium ethoxide or sodium amide, plays a critical role in the reaction's efficiency and the resulting cis/trans isomer ratio. The selection of appropriate reagents and reaction conditions is vital for achieving high yields and the desired purity of ethyl methylphenylglycidate.

The stability of the compound is also an important consideration for its industrial use. While relatively stable under neutral conditions, it is known to be unstable to alkali. Therefore, storage in inert containers and maintaining appropriate temperature conditions (typically 2-8°C) are recommended to preserve its quality. For bulk procurement, understanding these chemical properties ensures proper handling and storage to maintain the integrity of the product for its intended use, whether for flavor creation, fragrance development, or as a pharmaceutical intermediate.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing chemicals with well-defined properties and reliable synthesis routes. By offering Ethyl 3-Methyl-3-Phenylglycidate that adheres to strict quality standards, we support our clients in their endeavors to create innovative products across various industries.