In the complex world of pharmaceutical manufacturing, the selection of high-quality intermediates is as critical as the final active pharmaceutical ingredient (API) itself. 6-Methyl-5-hepten-2-one (CAS 110-93-0), also widely known as methyl heptenone, has carved out a significant niche as a versatile and indispensable pharmaceutical intermediate. Its unique chemical structure and reactivity make it a valuable building block for a wide range of therapeutic compounds. For R&D scientists and procurement managers, understanding the synthesis, properties, and reliable sourcing of this chemical is key.

Synthesis Pathways for 6-Methyl-5-hepten-2-one

The production of 6-Methyl-5-hepten-2-one involves several well-established synthetic routes, each with its own advantages and raw material dependencies. These commonly include:

  • From Acetylene and Acetone: This multi-step process involves ethynylation of acetone followed by partial hydrogenation and esterification, leading to the desired product through Carroll rearrangement.
  • From Isobutylene: Advanced catalytic processes, often employing isobutylene, acetone, and formaldehyde, can yield methyl heptenone. This route typically requires high temperatures and pressures, with ongoing research optimizing yields and minimizing side reactions.
  • From Isoprene: A process involving the reaction of isoprene with hydrogen chloride, followed by condensation with acetone, is another viable route. Improvements using phase transfer catalysts have enhanced efficiency and reduced waste.

As a leading manufacturer and supplier, we pride ourselves on employing efficient and high-yield synthetic methodologies to produce 6-Methyl-5-hepten-2-one that meets stringent pharmaceutical standards.

Applications in Pharmaceutical Development

The primary utility of 6-Methyl-5-hepten-2-one in the pharmaceutical industry lies in its function as a critical intermediate. It is instrumental in the synthesis of numerous compounds, including:

  • Vitamin Synthesis: It is a precursor in the production of essential vitamins like Vitamin A, Vitamin E, and Vitamin K1, crucial for human health.
  • Terpenoid Synthesis: It serves as a building block for various terpenoids, which are important in the development of pharmaceuticals and natural product-based medicines.
  • API Precursors: Its reactive ketone and alkene functionalities allow for diverse chemical modifications, making it a versatile starting material for synthesizing complex APIs.

When you purchase 6-Methyl-5-hepten-2-one from us, you are not just acquiring a chemical; you are gaining a reliable partner committed to supporting your pharmaceutical development pipeline. We offer high-purity grades (≥97%, ≥98%) and provide comprehensive documentation, including SDS and COA, to facilitate your regulatory compliance and research processes. For those looking to buy this vital pharmaceutical intermediate, inquire about our bulk pricing and sample availability.