As a leading supplier of specialty chemicals, understanding the fundamental science behind our products is crucial for our B2B clients. N,2,3-Trimethyl-2-isopropylbutamide, commonly recognized as WS-23, is a high-performance synthetic cooling agent with a unique chemical structure that dictates its desirable properties. For procurement managers and R&D scientists looking to buy premium ingredients, a deeper dive into its chemistry offers valuable insights. As a manufacturer, we emphasize the quality and precision in the synthesis of this compound.

The chemical name N,2,3-Trimethyl-2-isopropylbutamide, with the CAS number 51115-67-4, reveals a moderately complex organic molecule. Its molecular formula is C10H21NO, and it possesses a molecular weight of 171.28 g/mol. Structurally, it is an amide derivative featuring a branched alkyl chain, which contributes significantly to its sensory properties. The specific arrangement of methyl and isopropyl groups around the amide linkage is key to its ability to interact with cold-sensitive receptors in the human body, eliciting a cooling sensation without the inherent flavors or irritations often associated with menthol.

The synthesis of N,2,3-Trimethyl-2-isopropylbutamide typically involves sophisticated chemical pathways. One common route involves the Ritter reaction, a well-established method in organic synthesis for preparing amides. This process often starts with a suitable precursor, such as a nitrile or an alcohol, which is then reacted with an alkene or an alcohol in the presence of a strong acid, followed by hydrolysis. For WS-23, precursors like 2-isopropyl-N,2,3-trimethylbutyronitrile or similar structures are utilized. The precise reaction conditions, catalysts, and purification steps are critical to achieving the high purity levels (typically ≥99%) demanded by the market, especially for food-grade and cosmetic applications. When you buy WS-23, you're investing in a product of meticulous chemical engineering.

From a physical properties perspective, WS-23 typically presents as a white crystalline powder. Its melting point is generally in the range of 58-63°C, indicating its solid state at room temperature. Solubility is an important consideration for formulators; WS-23 is largely insoluble in water but exhibits good solubility in organic solvents like ethanol and oils, which is advantageous for creating concentrated flavor blends or incorporating it into various cosmetic bases. This solubility profile also contributes to its stability in different product matrices.

The distinctive sensory profile of WS-23 – its potent, long-lasting coolness with minimal odor and taste – is a direct consequence of its chemical structure. It interacts with the transient receptor potential melastatin 8 (TRPM8) channel, the same receptor targeted by menthol, but does so in a way that elicits a stronger and more sustained cooling response, often perceived as smoother and less sharp. This nuanced interaction makes it an exceptional ingredient for brands looking to buy an advanced cooling agent.

For companies seeking to source N,2,3-Trimethyl-2-isopropylbutamide, understanding these chemical underpinnings highlights why quality and purity are paramount. As a leading manufacturer and supplier, we ensure our WS-23 meets stringent specifications. We encourage product developers and chemists to consider the chemical elegance and functional superiority of WS-23 for their innovative formulations. Reach out to us to buy this advanced cooling agent and discover its full potential.