Human iron metabolism is a tightly regulated process essential for numerous physiological functions. At the heart of this system lies Human Holo-Transferrin, the primary iron-transporting protein in the blood plasma. Understanding its function is key to comprehending how the body maintains iron balance. NINGBO INNO PHARMCHEM CO.,LTD. is a reliable source for this vital biomolecule.

Human Holo-Transferrin is a glycoprotein that binds iron ions in the plasma, facilitating their transport from absorption sites in the intestine and from degrading red blood cells to various tissues, including the bone marrow, liver, and muscles. This transport system ensures that iron is available for essential cellular processes like hemoglobin synthesis, DNA replication, and energy production. The protein has two specific iron-binding sites, allowing it to carry two ferric ions per molecule. This efficient transport mechanism is critical for preventing iron deficiency anemia and iron overload conditions like hemochromatosis.


The process begins with iron absorption in the duodenum, where it is bound by transferrin in the plasma. Holo-Transferrin then circulates through the body and binds to transferrin receptors (CD71) present on the surface of cells. This binding event triggers the internalization of the Holo-Transferrin-receptor complex, allowing the release of iron into the cell. The precise regulation of iron levels mediated by Holo-Transferrin is fundamental for overall health. It's not just about transporting iron; it's about delivering it safely and efficiently where it's needed most.


The importance of Human Holo-Transferrin extends beyond its role in simple iron transport. It also possesses antioxidant properties by scavenging free iron, which can otherwise generate harmful reactive oxygen species. In the context of research and diagnostics, Human Holo-Transferrin is a valuable reagent. It is used in cell culture media to support cell growth, in biochemical assays to study iron binding kinetics, and as a reference standard for clinical diagnostic tests related to iron metabolism. For those seeking to purchase Human Holo-Transferrin for these purposes, NINGBO INNO PHARMCHEM CO.,LTD. offers a high-quality product.


NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with reliable and pure Human Holo-Transferrin. Our products are manufactured under strict quality controls to ensure their efficacy in various applications. Whether your research focuses on hematology, cellular metabolism, or drug development related to iron regulation, our Holo-Transferrin is an excellent choice. To buy Human Holo-Transferrin and contribute to advancements in understanding human iron metabolism, contact NINGBO INNO PHARMCHEM CO.,LTD.