For chemists and researchers involved in organic synthesis, a deep understanding of a chemical intermediate's properties and synthesis pathways is fundamental to its effective utilization. 2,3-Dichloroquinoxaline (CAS 2213-63-0) is one such compound, a versatile building block prized for its reactivity and its role in constructing complex heterocyclic systems. Whether you are looking to purchase this compound for OLED material development or pharmaceutical synthesis, appreciating its chemical characteristics is paramount.

Chemically, 2,3-Dichloroquinoxaline possesses the molecular formula C8H4Cl2N2 and a molecular weight of approximately 199.04 g/mol. It typically presents as an off-white to light brown solid, with a melting point often cited in the range of 150-154 °C. Its density is around 1.487 g/cm³. A critical aspect of its chemistry is the presence of two chlorine atoms attached to the quinoxaline ring. These chlorine atoms are susceptible to nucleophilic aromatic substitution (SNAr) reactions, making 2,3-Dichloroquinoxaline an excellent electrophilic substrate. This reactivity allows for the facile introduction of various nucleophiles, such as amines, alcohols, thiols, and organometallic reagents, leading to a wide array of substituted quinoxaline derivatives.

The synthesis of 2,3-Dichloroquinoxaline commonly involves the chlorination of quinoxaline-2,3(1H,4H)-dione (also known as 2,3-dihydroxyquinoxaline). A typical method involves reacting quinoxaline-2,3-dione with phosphoryl chloride (POCl3), often in the presence of a solvent like N,N-dimethylformamide (DMF), and heating the mixture under reflux. Following the reaction, the product is usually isolated by quenching the reaction mass with ice-cold water, neutralization, filtration, and subsequent purification, often via recrystallization or chromatography. This process can yield the desired intermediate in excellent yields, a fact of great interest to any potential manufacturer looking to scale up production.

When considering the procurement of this compound, understanding these synthesis routes and chemical properties can provide valuable insight into the potential purity profiles and handling requirements. For buyers looking to secure a consistent supply, partnering with a reputable supplier who can demonstrate robust manufacturing capabilities and quality control protocols is essential. Knowing that the material you buy has been synthesized efficiently and purified effectively by a trusted manufacturer can streamline your R&D efforts and ensure the success of your downstream applications. The ability to obtain this crucial intermediate with guaranteed purity and a competitive price is a significant advantage in today's market.