The pharmaceutical industry constantly seeks efficient and versatile building blocks for synthesizing novel drug candidates. In this quest, 6-Bromobenzo[b]thiophene (CAS 17347-32-9) has emerged as a compound of significant interest. As a key pharmaceutical intermediate, its unique chemical structure and reactivity make it an invaluable asset for drug discovery and development programs worldwide. For procurement professionals and research scientists, understanding its utility and how to source it effectively from reliable manufacturers is crucial.

Understanding the Chemical Profile of 6-Bromobenzo[b]thiophene

6-Bromobenzo[b]thiophene, with the chemical formula C8H5BrS, is a brominated derivative of benzothiophene. Its CAS number, 17347-32-9, is a critical identifier for sourcing and regulatory purposes. This compound typically appears as a powder ranging in color from white to yellow or brown, with a melting point between 56-60°C. The bromine atom strategically positioned on the benzothiophene ring significantly enhances its reactivity in various organic transformations, particularly palladium-catalyzed cross-coupling reactions.

Applications in Drug Discovery and Development

The primary appeal of 6-Bromobenzo[b]thiophene in the pharmaceutical sector lies in its role as a versatile synthon. Pharmaceutical chemists utilize it to construct complex molecular scaffolds that form the basis of many active pharmaceutical ingredients (APIs). Its ability to undergo coupling reactions allows for the introduction of diverse functional groups and the creation of intricate heterocyclic systems, which are common features in many therapeutically active molecules. Researchers exploring new treatments for various diseases, including cancer and inflammatory conditions, often rely on such specialized intermediates to build their target compounds efficiently.

Key Advantages for Pharmaceutical Manufacturers

When sourcing pharmaceutical intermediates, purity and consistency are non-negotiable. 6-Bromobenzo[b]thiophene, with a minimum purity of 97% (often >98% by HPLC), ensures that synthetic pathways are reliable and that the final APIs meet stringent quality standards. Its availability from leading manufacturers in China provides an advantage in terms of cost-effectiveness and supply chain stability. For R&D scientists and purchasing managers, securing a dependable supply of this intermediate is vital for maintaining project timelines and managing research budgets.

Where to Buy and How to Procure

Identifying a reputable manufacturer or supplier for 6-Bromobenzo[b]thiophene is the first step for any pharmaceutical company or research institution. Look for suppliers who can offer comprehensive documentation, including detailed specifications, COAs, and MSDS. Companies often seek to buy in quantities ranging from grams for early-stage research to kilograms for scale-up synthesis. Engaging with manufacturers who provide custom synthesis services can also be beneficial for unique project requirements.

Conclusion

6-Bromobenzo[b]thiophene (CAS 17347-32-9) is more than just a chemical intermediate; it's a catalyst for innovation in pharmaceutical research. Its utility in constructing complex, bioactive molecules makes it an indispensable tool for drug discovery. By understanding its importance and sourcing it from trusted China-based suppliers, the pharmaceutical industry can accelerate the development of life-saving medications.