The field of organic chemistry thrives on the understanding and manipulation of molecular properties. For synthetic chemists, a deep dive into the characteristics of key building blocks is essential for designing efficient and successful reaction pathways. One such versatile compound that has garnered significant attention is 2-Bromo-4-methylquinoline, identified by CAS number 64658-04-4.

At its core, 2-Bromo-4-methylquinoline is a functionalized quinoline, a bicyclic aromatic heterocycle. Its molecular formula, C10H8BrN, and a molecular weight of approximately 222.08 g/mol, provide a foundation for understanding its behavior. The compound typically presents as a white powder, with a melting point in the range of 80-90°C, indicating it is a solid under standard conditions. Its boiling point at 760 mmHg is around 313.7°C, suggesting it is thermally stable for many common synthetic operations.

The true utility of 2-Bromo-4-methylquinoline lies in its chemical reactivity, primarily driven by the bromine atom. This halogen substituent makes the molecule an excellent substrate for a variety of transformations. Palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura coupling, are highly effective for introducing aryl or alkyl groups at the 2-position, thereby expanding the molecular complexity. These reactions are crucial for creating conjugated systems used in electronic materials and for constructing complex scaffolds in medicinal chemistry.

Furthermore, the bromine can be displaced by nucleophiles, opening pathways for introducing amine, thiol, or alkoxide functionalities. This reactivity makes it a valuable intermediate for synthesizing nitrogen-containing heterocycles and other functionalized organic molecules. For researchers aiming to buy this compound, seeking a supplier that guarantees high purity, typically 97% or above, is paramount to ensure successful and reproducible synthetic outcomes.

In summary, the chemical properties of 2-Bromo-4-methylquinoline, particularly its reactivity at the bromine site, position it as a highly sought-after building block in modern organic synthesis. Whether for developing new OLED materials or exploring novel pharmaceutical agents, understanding and utilizing these properties is key for chemists aiming to innovate.