In the ongoing battle against infectious diseases, the scientific community is constantly seeking novel therapeutic agents. Indole-3-Carbinol (I3C), a compound naturally found in cruciferous vegetables, has emerged as a molecule of significant interest due to its demonstrated antiviral activity, most notably against the SARS-CoV-2 virus. This research opens up exciting avenues for natural compounds in public health. Early in vitro studies have shown that I3C exhibits direct anti-SARS-CoV-2 replication activity. Importantly, the compound has demonstrated efficacy against the Omicron variant as well. The proposed mechanism involves I3C's interaction with host cell pathways crucial for viral replication and egress, suggesting a host-targeted approach that could be effective against emerging viral strains. The investigation of Indole-3-Carbinol antiviral activity is a rapidly evolving field, offering hope for new treatment strategies. Furthermore, I3C has been observed to modulate the expression of genes involved in innate immunity and inflammatory responses. In human lung organoids infected with SARS-CoV-2, I3C treatment led to a reduction in pro-inflammatory cytokines and interferons, suggesting a role in tempering the overactive immune responses that can contribute to severe COVID-19 outcomes. This immunomodulatory effect, coupled with its direct antiviral action, positions I3C as a promising candidate for further clinical investigation. While the preclinical data is compelling, ongoing research aims to fully elucidate the therapeutic potential of I3C. As a natural compound, its safety profile is also a key consideration. Preclinical toxicity studies indicate that I3C is generally well-tolerated at effective doses, with a favorable safety margin. NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality Indole-3-Carbinol for scientific research, supporting the development of natural antiviral solutions.