The pharmaceutical industry relies heavily on a diverse range of high-purity chemical intermediates to synthesize active pharmaceutical ingredients (APIs) and other crucial drug components. Among these, 1,12-Dodecanediol (CAS 5675-51-4) stands out as a versatile building block with significant utility in complex organic syntheses. This article explores the importance of 1,12-Dodecanediol in pharmaceutical R&D and manufacturing, and offers guidance on how to efficiently source it from reliable suppliers.

The Chemical Profile of 1,12-Dodecanediol

1,12-Dodecanediol is an organic compound characterized by its linear twelve-carbon backbone, terminated by hydroxyl groups at both ends. This difunctional nature makes it an ideal starting material or intermediate for a variety of chemical reactions, including esterification, etherification, and polymerization. Its consistent appearance as a white to off-white powder or lump, coupled with a good purity profile (often 97%min or higher), ensures predictable reaction outcomes in sensitive pharmaceutical processes.

Applications in Pharmaceutical Synthesis

The utility of 1,12-Dodecanediol in pharmaceutical synthesis stems from its ability to introduce specific structural features or act as a linker molecule. Its applications include:

  • Synthesis of APIs: It can be a precursor in the multi-step synthesis of various drug molecules, where its long carbon chain or reactive hydroxyl groups are strategically incorporated into the final API structure.
  • Linker Molecules: In drug delivery systems or bioconjugation, diols like 1,12-Dodecanediol can serve as flexible linkers, connecting different molecular entities or drug payloads to targeting agents.
  • Excipients: In some formulations, its properties might lend themselves to use as an excipient, potentially aiding in solubility or stability of the drug product, although this is a less common primary application.

For researchers and development scientists, ensuring a consistent supply of high-quality 1,12-Dodecanediol is crucial for the reproducibility and scalability of their synthetic routes. This is where the importance of sourcing from reputable chemical manufacturers and suppliers becomes evident.

Sourcing Strategies for Pharmaceutical Intermediates

When seeking to buy 1,12-Dodecanediol for pharmaceutical applications, attention to detail is key. Procurement managers should look for:

  • Verified Purity: Certificates of Analysis (COAs) are essential, detailing purity levels and the absence of critical impurities.
  • Manufacturing Standards: While not always requiring GMP for early-stage intermediates, understanding the manufacturer's quality control processes is vital.
  • Reliable Supply Chain: A consistent supply is necessary for long-term projects. Partnering with a trusted supplier or manufacturer with robust production capabilities is paramount.
  • Competitive Pricing: Obtaining competitive pricing for this intermediate can significantly impact the overall cost of API production.

NINGBO INNO PHARMCHEM, as a dedicated manufacturer and supplier of organic chemistry intermediates, offers high-purity 1,12-Dodecanediol to the pharmaceutical sector. We are committed to providing quality materials, competitive prices, and reliable delivery from our facilities in China. For any inquiries regarding 1,12-Dodecanediol price or to discuss your specific synthesis needs, please do not hesitate to contact us.