The pharmaceutical industry demands intermediates of exceptional purity and consistent quality for the synthesis of active pharmaceutical ingredients (APIs) and other critical compounds. 1-Chlorohexadecane, bearing the CAS number 4860-03-1, serves as a valuable organic intermediate in this sector. This article delves into the properties of 1-Chlorohexadecane and its specific applications within pharmaceutical synthesis, offering insights for researchers and procurement professionals.

1-Chlorohexadecane is an organochlorine compound characterized by a long, saturated hydrocarbon chain (C16) and a terminal chlorine atom. Its molecular formula is C16H33Cl, with a molecular weight of approximately 260.89 g/mol. Typically presented as a clear, colorless to pale yellow liquid, it possesses a mild odor. Its physical state at room temperature is liquid, with a melting point generally reported in the range of 8-14°C, meaning it remains fluid under standard laboratory and storage conditions. While sparingly soluble in water, it dissolves well in common organic solvents like ethanol, ether, and chloroform, which is advantageous for its use in various synthetic protocols.

In pharmaceutical synthesis, 1-Chlorohexadecane primarily functions as an alkylating agent. Its long hydrophobic tail, combined with the reactive chlorine atom, makes it suitable for introducing the hexadecyl group into various molecules. This process is crucial for creating specific cetylated derivatives, which can be important components in formulating topical medications, cosmetic ingredients, or as building blocks for more complex APIs. Researchers and developers often look to buy such intermediates to tailor the physicochemical properties of their target compounds, such as lipophilicity or membrane interaction.

The sourcing of 1-Chlorohexadecane for pharmaceutical applications requires stringent quality control. Suppliers typically provide material with a purity of 98% or higher, often verified by Gas Chromatography (GC). Accompanying documentation, such as Certificates of Analysis (CoA), should detail impurity profiles and assay results. For companies looking to buy in bulk, working with established manufacturers, particularly those with a strong presence in regions like China, can offer competitive pricing and reliable delivery schedules.

The process of purchasing 1-Chlorohexadecane involves understanding its specifications and the supplier's capabilities. Key considerations include the grade of purity, available packaging (often in drums), and compliance with international safety and handling standards. For pharmaceutical R&D, smaller quantities might be sufficient, while large-scale manufacturing will necessitate bulk purchasing from dedicated suppliers. The cost of this intermediate can be influenced by market demand and production scale.

In conclusion, 1-Chlorohexadecane (CAS 4860-03-1) is a valuable organic intermediate for the pharmaceutical industry, enabling the synthesis of important derivatives. Its chemical properties make it a versatile alkylating agent. For researchers and manufacturers seeking to buy this compound, prioritizing purity, reliable sourcing from experienced suppliers, and competitive pricing are key factors for successful project execution and product development.