In the dynamic world of biochemical research and development, precise protein modification is paramount. Whether for creating diagnostic assays, developing targeted therapies, or engineering novel biomaterials, the ability to specifically alter protein structures is essential. Among the critical reagents enabling these advancements, 1,6-Bis-Maleimidohexane (CAS 4856-87-5) emerges as a highly effective homobifunctional crosslinking agent. As a premier supplier, we are dedicated to providing researchers with this indispensable tool to purchase for their critical applications.

1,6-Bis-Maleimidohexane is characterized by its dual maleimide functionalities, linked by a six-carbon aliphatic chain. This structure makes it an ideal reagent for covalently bridging two molecules that contain sulfhydryl groups. The reaction proceeds via a Michael addition mechanism, where the nucleophilic sulfur atom of a thiol attacks the electrophilic double bond of the maleimide ring, forming a stable thioether bond. This reaction is highly specific, occurring efficiently under mild conditions, typically at a slightly alkaline pH (6.5-7.5).

The utility of 1,6-Bis-Maleimidohexane spans several key areas in biotechnology and pharmaceutical research. Its primary application lies in protein crosslinking, where it can be used to stabilize protein structures, investigate protein-protein interactions, or create dimeric or multimeric protein complexes. For instance, researchers often buy this reagent to create protein-based biomaterials, such as hydrogels, where controlled crosslinking dictates the mechanical properties and degradation profiles of the material. The 16.1 Angstrom spacer arm length it provides offers a balance between flexibility and structural rigidity, which is often desired in these applications.

Furthermore, 1,6-Bis-Maleimidohexane is a valuable component in the synthesis of antibody-drug conjugates (ADCs). By using this crosslinker to attach payloads to antibodies, researchers can create potent therapeutic agents. The reliability of the thioether linkage ensures that the drug remains covalently bound to the antibody until it is delivered to the target cell, enhancing therapeutic efficacy and reducing off-target effects. Sourcing high-purity 1,6-Bis-Maleimidohexane from a reputable manufacturer is crucial for the success of such sensitive applications.

We understand the critical role this reagent plays in scientific advancement. Therefore, we pride ourselves on being a trusted manufacturer and supplier, offering 1,6-Bis-Maleimidohexane with a guaranteed purity of ≥98.0%. This commitment to quality ensures that your purchase will meet the stringent demands of your research and development projects. Whether you need to buy for academic research or industrial production, our product provides the specificity and stability required for successful protein modification and the creation of innovative biomolecular solutions.