3-Fluoro-4-methoxyphenol: Exploring Synthesis Routes and Chemical Properties
3-Fluoro-4-methoxyphenol, identified by CAS number 452-11-9, is a fluorinated aromatic compound that serves as a valuable intermediate in organic chemistry and pharmaceutical synthesis. Its molecular formula, C7H7FO2, outlines a structure amenable to diverse chemical transformations. Understanding its synthesis pathways and intrinsic chemical properties is fundamental for researchers aiming to leverage its potential effectively.
The synthesis of 3-fluoro-4-methoxyphenol often involves meticulous procedures to achieve high purity. As mentioned in chemical literature, a common approach includes the deprotection of precursor compounds, such as the acetate ester of 3-fluoro-4-methoxyphenol, typically carried out in an alcoholic solvent with a base like sodium hydroxide. Subsequent work-up procedures involving acidification, extraction, and purification through recrystallization are critical to isolate the desired product with the required specifications. Researchers often seek optimized synthesis protocols to enhance yield and reduce production costs.
Key chemical properties of 3-fluoro-4-methoxyphenol include its physical appearance, often described as a light yellow to brown solid. While specific properties like melting point can vary slightly between batches and suppliers (commonly cited around 41-47°C or 54-55°C), these values are important indicators of purity. The compound's pKa value, predicted to be around 9.46±0.18, suggests its behavior in solution and its potential reactivity. Understanding these properties helps in handling, storage, and reaction design when using it as a building block for molecules like non-peptidic NPBWR1 (GPR7) antagonists.
For chemical buyers, verifying these properties through reliable 3-fluoro-4-methoxyphenol supplier channels, particularly from China, is essential. Access to detailed technical data sheets (TDS) and sample analysis reports allows for informed purchasing decisions. Whether for laboratory research or industrial application, a thorough grasp of the synthesis and chemical characteristics of 3-fluoro-4-methoxyphenol ensures its successful integration into complex chemical projects.
The synthesis of 3-fluoro-4-methoxyphenol often involves meticulous procedures to achieve high purity. As mentioned in chemical literature, a common approach includes the deprotection of precursor compounds, such as the acetate ester of 3-fluoro-4-methoxyphenol, typically carried out in an alcoholic solvent with a base like sodium hydroxide. Subsequent work-up procedures involving acidification, extraction, and purification through recrystallization are critical to isolate the desired product with the required specifications. Researchers often seek optimized synthesis protocols to enhance yield and reduce production costs.
Key chemical properties of 3-fluoro-4-methoxyphenol include its physical appearance, often described as a light yellow to brown solid. While specific properties like melting point can vary slightly between batches and suppliers (commonly cited around 41-47°C or 54-55°C), these values are important indicators of purity. The compound's pKa value, predicted to be around 9.46±0.18, suggests its behavior in solution and its potential reactivity. Understanding these properties helps in handling, storage, and reaction design when using it as a building block for molecules like non-peptidic NPBWR1 (GPR7) antagonists.
For chemical buyers, verifying these properties through reliable 3-fluoro-4-methoxyphenol supplier channels, particularly from China, is essential. Access to detailed technical data sheets (TDS) and sample analysis reports allows for informed purchasing decisions. Whether for laboratory research or industrial application, a thorough grasp of the synthesis and chemical characteristics of 3-fluoro-4-methoxyphenol ensures its successful integration into complex chemical projects.
Perspectives & Insights
Future Origin 2025
“As mentioned in chemical literature, a common approach includes the deprotection of precursor compounds, such as the acetate ester of 3-fluoro-4-methoxyphenol, typically carried out in an alcoholic solvent with a base like sodium hydroxide.”
Core Analyst 01
“Subsequent work-up procedures involving acidification, extraction, and purification through recrystallization are critical to isolate the desired product with the required specifications.”
Silicon Seeker One
“Researchers often seek optimized synthesis protocols to enhance yield and reduce production costs.”