Chemical biology relies on precisely engineered molecules to probe biological systems, develop new diagnostics, and create targeted therapeutics. Among the array of essential reagents, 3-Maleimidopropionic Acid (CAS 7423-55-4) stands out as a highly versatile intermediate, facilitating complex molecular constructions. As a dedicated manufacturer and supplier in China, we understand its importance and offer high-purity material to researchers in the chemical biology field. This article details its role and benefits.

Understanding the Chemistry of 3-Maleimidopropionic Acid

3-Maleimidopropionic Acid is a heterobifunctional molecule possessing a maleimide group and a carboxylic acid group. This dual functionality allows it to react selectively with different types of molecules:

  • Maleimide Reactivity: The maleimide group exhibits high specificity for reaction with thiol (-SH) groups. This reaction forms a stable thioether bond, making it ideal for conjugating thiolated molecules, such as cysteine-containing peptides or proteins, to other substrates.
  • Carboxylic Acid Reactivity: The terminal carboxylic acid group can be activated (e.g., using carbodiimides like EDC) to form amide bonds with primary amine (-NH2) groups. This enables the attachment of amine-containing molecules, including amino-modified surfaces, labels, or drug molecules.

Applications in Chemical Biology

The unique reactivity profile of 3-Maleimidopropionic Acid makes it an invaluable tool for chemical biologists:

  • Biomolecule Labeling: It is extensively used to label proteins, antibodies, or nucleic acids with fluorescent dyes, biotin, or other reporter molecules. By first conjugating the reporter molecule to the carboxylic acid end and then using the maleimide to attach it to a thiol-containing biomolecule, researchers can visualize, track, and quantify biological processes. If you need to buy 3-Maleimidopropionic Acid for labeling experiments, our high-purity product is an excellent choice.
  • Development of Assays and Biosensors: The ability to immobilize biomolecules onto surfaces is critical for developing sensitive diagnostic assays and biosensors. 3-Maleimidopropionic Acid can be used to covalently attach thiolated capture molecules to amine-functionalized surfaces, or vice versa, creating platforms for detecting specific analytes.
  • Crosslinking Studies: It can be employed in studies to understand protein-protein interactions or to stabilize protein structures by acting as a crosslinker, covalently joining specific amino acid residues.
  • Synthesis of Bio-inspired Materials: Its ability to form stable linkages also finds use in creating sophisticated biomaterials for drug delivery, tissue engineering, and nanotechnology applications.

Your Trusted Supplier in China

As a leading manufacturer and supplier of fine chemicals, we are committed to providing researchers with the highest quality 3-Maleimidopropionic Acid. Our rigorous quality control ensures product purity, vital for the success of sensitive chemical biology experiments. By sourcing from us, you benefit from competitive prices, a reliable supply chain, and expert technical support. We are dedicated to facilitating your research breakthroughs.

Inquire About Our Products

For those seeking to purchase 3-Maleimidopropionic Acid for their chemical biology research, we invite you to request a quote. Discover how our commitment to quality and our extensive experience as a chemical manufacturer can support your innovative projects. Partner with us for your chemical needs and advance your scientific discoveries.