4-Bromo-2-(methylsulfonyl)pyrimidine, identified by CAS number 1208538-52-6, is a significant compound in the realm of organic chemistry, serving as a versatile intermediate for a multitude of synthetic transformations. Its distinct chemical structure and properties make it an indispensable tool for researchers engaged in creating novel molecules for various applications, from pharmaceuticals to advanced materials. This article provides an in-depth look at its key characteristics and its critical role in chemical synthesis.

Understanding the physical and chemical properties of 4-Bromo-2-(methylsulfonyl)pyrimidine is fundamental to its effective utilization. This compound typically appears as an off-white solid with a melting point in the range of 111-112°C. Its molecular formula is C5H5BrN2O2S, and it has a molecular weight of approximately 237.07 g/mol. These properties are vital for handling, storage, and reaction planning. The presence of both a bromine atom and a methylsulfonyl group on the pyrimidine ring offers multiple avenues for chemical modification, making it a strategic choice for chemists.


In terms of synthesis applications, 4-Bromo-2-(methylsulfonyl)pyrimidine excels as a versatile building block. The bromine atom is an excellent leaving group, readily participating in palladium-catalyzed cross-coupling reactions such as Suzuki, Stille, and Buchwald-Hartwig couplings. These reactions are essential for forming carbon-carbon and carbon-heteroatom bonds, allowing for the introduction of complex side chains or functional groups onto the pyrimidine core. The methylsulfonyl group, an electron-withdrawing group, influences the reactivity of the pyrimidine ring and can also be subject to further transformations or serve as a key feature in the final molecular structure.


The compound is frequently employed in the synthesis of biologically active molecules. Researchers utilize it to construct novel heterocyclic frameworks that form the basis of many pharmaceutical agents. Its structural motif is relevant in the development of kinase inhibitors, antiviral agents, and other therapeutic compounds. Beyond pharmaceuticals, it finds applications in materials science, where its derivatives can be incorporated into organic electronic materials, dyes, or other functional substances.


When chemists need to buy 4-Bromo-2-(methylsulfonyl)pyrimidine, they often look for high-purity grades to ensure the success of sensitive synthetic steps. The reliability of the supply chain and the consistency of product quality are paramount. As a dependable manufacturer in China, our commitment is to provide researchers with this critical intermediate, facilitating progress in their innovative projects. The ability to buy such a versatile compound ensures that research programs can proceed efficiently.


In conclusion, 4-Bromo-2-(methylsulfonyl)pyrimidine is more than just a chemical; it is an enabler of scientific discovery. Its well-defined properties and broad synthesis applications underscore its importance in modern organic chemistry. For researchers aiming to push the boundaries of molecular design and synthesis, this compound remains an essential tool in their repertoire.