4-Bromobenzyl Alcohol, identified by its CAS number 873-75-6, is a fundamental organic compound that plays a pivotal role in a myriad of chemical synthesis processes. This aromatic alcohol derivative, characterized by the presence of a bromine atom at the para position of the benzyl ring, offers a unique combination of functional groups that chemists leverage for intricate molecular construction. Understanding its detailed properties and chemical reactivity is key to optimizing its use in research and industrial applications.

The molecular formula for 4-Bromobenzyl Alcohol is C7H7BrO, and its molecular weight is approximately 187.03 g/mol. Typically presenting as a white crystalline powder or crystals, it exhibits a melting point in the range of 75-77 °C. This solid state at room temperature, combined with its solubility in organic solvents like dioxane, makes it relatively easy to handle and incorporate into reaction mixtures. The stability of 4-Bromobenzyl Alcohol under recommended storage conditions further enhances its appeal as a reliable chemical intermediate.

The reactivity of 4-Bromobenzyl Alcohol stems from its two primary functional sites: the primary alcohol (-CH2OH) and the aryl bromide (Ar-Br). The alcohol group can readily participate in reactions such as esterification, etherification, oxidation to the corresponding aldehyde or carboxylic acid, and halogenation. The aryl bromide moiety is particularly valuable for cross-coupling reactions, including Suzuki-Miyaura coupling, Heck reaction, Sonogashira coupling, and Buchwald-Hartwig amination. These palladium-catalyzed reactions are indispensable tools for forming carbon-carbon and carbon-heteroatom bonds, enabling the construction of complex molecular architectures.

Chemists seeking to buy 4-bromobenzyl alcohol will often prioritize its purity. High purity ensures predictable reaction outcomes and minimizes the formation of unwanted by-products, which is especially critical in pharmaceutical intermediate synthesis. The availability of 4-bromobenzyl alcohol from various chemical suppliers means researchers can access this compound for diverse synthetic strategies, from creating novel drug candidates to developing advanced materials. The established 4-bromobenzyl alcohol synthesis methods contribute to its consistent availability and quality.

The role of 4-bromobenzyl alcohol extends beyond mere laboratory curiosity; it is a workhorse chemical that underpins significant industrial processes. Its ability to act as a key building block in the synthesis of various organic compounds makes it a staple in the arsenal of synthetic chemists. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are instrumental in ensuring the continuous supply of such vital intermediates, facilitating progress across multiple scientific disciplines.