4-Bromocrotonic Acid: Inhibiting Fatty Acid Oxidation for Metabolic Research
Metabolic research plays a pivotal role in understanding human health and disease, particularly concerning energy utilization within cells. Fatty acid oxidation is a cornerstone of this process, and understanding its regulation is key to addressing metabolic dysfunctions like insulin resistance and obesity. In this critical area of study, 4-Bromocrotonic acid (CAS 20629-35-0) emerges as a powerful investigative tool.
This compound, chemically known as (E)-4-bromobut-2-enoic acid, is recognized for its significant biological activity as an inhibitor of fatty acid oxidation. Fatty acids are primarily metabolized through beta-oxidation within the mitochondria, a process that requires the transport of fatty acids into the mitochondrial matrix. This transport is facilitated by carnitine palmitoyltransferase I (CPT-1), a rate-limiting enzyme in this pathway.
4-Bromocrotonic acid effectively targets this critical step by inhibiting CPT-1. This inhibition leads to a disruption in the normal flow of fatty acids into the mitochondria for energy production. As a result, fatty acids tend to accumulate in the cytoplasm. This mechanism allows researchers to experimentally induce a state of reduced fatty acid oxidation, mimicking certain conditions observed in metabolic diseases.
The ability of 4-Bromocrotonic acid to interfere with fatty acid metabolism provides invaluable insights into cellular energy regulation. Scientists can use it to study how cells respond to a limited supply of fatty acids for oxidation, explore alternative energy substrates, and investigate the consequences of impaired mitochondrial function. This research is crucial for understanding the pathogenesis of metabolic disorders and for identifying potential therapeutic targets.
Furthermore, studies have indicated that the enzymatic conversion of 4-Bromocrotonic acid can lead to the formation of inhibitory intermediates, such as 3-keto-4-bromobutyryl-CoA, which further impede respiration supported by fatty acids. This multifaceted action underscores its utility in detailed biochemical investigations.
NINGBO INNO PHARMCHEM CO.,LTD., a reputable manufacturer and supplier from China, provides high-quality 4-Bromocrotonic acid to support these vital research endeavors. Our commitment to purity and consistency ensures that researchers have access to a reliable tool for their studies on fatty acid metabolism and cellular energy regulation. By employing 4-Bromocrotonic acid, scientists can gain a deeper understanding of metabolic pathways and contribute to the development of new strategies for managing metabolic health.
This compound, chemically known as (E)-4-bromobut-2-enoic acid, is recognized for its significant biological activity as an inhibitor of fatty acid oxidation. Fatty acids are primarily metabolized through beta-oxidation within the mitochondria, a process that requires the transport of fatty acids into the mitochondrial matrix. This transport is facilitated by carnitine palmitoyltransferase I (CPT-1), a rate-limiting enzyme in this pathway.
4-Bromocrotonic acid effectively targets this critical step by inhibiting CPT-1. This inhibition leads to a disruption in the normal flow of fatty acids into the mitochondria for energy production. As a result, fatty acids tend to accumulate in the cytoplasm. This mechanism allows researchers to experimentally induce a state of reduced fatty acid oxidation, mimicking certain conditions observed in metabolic diseases.
The ability of 4-Bromocrotonic acid to interfere with fatty acid metabolism provides invaluable insights into cellular energy regulation. Scientists can use it to study how cells respond to a limited supply of fatty acids for oxidation, explore alternative energy substrates, and investigate the consequences of impaired mitochondrial function. This research is crucial for understanding the pathogenesis of metabolic disorders and for identifying potential therapeutic targets.
Furthermore, studies have indicated that the enzymatic conversion of 4-Bromocrotonic acid can lead to the formation of inhibitory intermediates, such as 3-keto-4-bromobutyryl-CoA, which further impede respiration supported by fatty acids. This multifaceted action underscores its utility in detailed biochemical investigations.
NINGBO INNO PHARMCHEM CO.,LTD., a reputable manufacturer and supplier from China, provides high-quality 4-Bromocrotonic acid to support these vital research endeavors. Our commitment to purity and consistency ensures that researchers have access to a reliable tool for their studies on fatty acid metabolism and cellular energy regulation. By employing 4-Bromocrotonic acid, scientists can gain a deeper understanding of metabolic pathways and contribute to the development of new strategies for managing metabolic health.
Perspectives & Insights
Bio Analyst 88
“This transport is facilitated by carnitine palmitoyltransferase I (CPT-1), a rate-limiting enzyme in this pathway.”
Nano Seeker Pro
“This inhibition leads to a disruption in the normal flow of fatty acids into the mitochondria for energy production.”
Data Reader 7
“This mechanism allows researchers to experimentally induce a state of reduced fatty acid oxidation, mimicking certain conditions observed in metabolic diseases.”