In the realm of advanced chemistry, specific molecular structures serve as indispensable tools for innovation. 4-Chloro-2,2'-bipyridine (CAS 14162-94-8) stands out as a versatile heterocyclic compound, prized for its unique properties and broad applicability, particularly in coordination chemistry and complex organic synthesis. For researchers and industrial chemists, understanding its chemical behavior and sourcing it reliably is key to unlocking new possibilities.

Chemical Properties and Structure of 4-Chloro-2,2'-bipyridine

The molecular architecture of 4-Chloro-2,2'-bipyridine consists of two pyridine rings joined by a single bond, with a chlorine atom strategically placed at the 4-position of one ring. This structure makes it an excellent bidentate ligand, capable of forming stable complexes with various metal ions. The electronegative chlorine atom influences the electronic distribution within the molecule, affecting its reactivity and coordination behavior. Typically appearing as an off-white solid, its solubility in common organic solvents facilitates its use in solution-phase reactions. The CAS number 14162-94-8 is critical for precise identification and sourcing from chemical suppliers.

Role in Coordination Chemistry

As a ligand, 4-Chloro-2,2'-bipyridine is instrumental in the field of coordination chemistry. Its nitrogen atoms readily chelate to metal centers, forming complexes with diverse applications. These metal complexes are often employed as catalysts in various organic transformations, including polymerization, oxidation, and reduction reactions. The specific electronic and steric properties imparted by the chloro substituent can fine-tune the catalytic activity and selectivity of the metal center, making it a valuable component in the design of highly efficient catalysts. For scientists looking to purchase this compound for such applications, ensuring high purity is essential for reproducible results.

Utility in Organic Synthesis

Beyond coordination chemistry, 4-Chloro-2,2'-bipyridine serves as a crucial intermediate in organic synthesis. The chlorine atom acts as a reactive handle, allowing for further functionalization through nucleophilic aromatic substitution (SNAr) or cross-coupling reactions such as Suzuki, Stille, or Buchwald-Hartwig couplings. These transformations enable the construction of more complex molecular architectures, including pharmaceuticals, agrochemicals, and advanced materials. Procurement of this intermediate from reliable chemical manufacturers ensures a consistent supply for research and development projects and for scaling up production.

Sourcing and Commercial Availability

For industrial buyers and research institutions, sourcing high-quality 4-Chloro-2,2'-bipyridine is a critical step. Manufacturers and chemical suppliers offer this compound in various quantities, from grams for laboratory use to kilograms for pilot-scale production. When inquiring about price and availability, it is important to specify the desired purity and quantity. Reputable suppliers often provide detailed product specifications and support, ensuring that you receive a product that meets your exact needs. Engaging with a trusted chemical supplier, especially one with expertise in heterocyclic compounds, guarantees access to this essential building block for your chemical endeavors.