For chemists engaged in organic synthesis, the availability of versatile and reliable building blocks is critical for the advancement of research and development. 4-Phenyl-2-butanol (CAS 2344-70-9), also recognized as alpha-methyl-benzenepropanol, stands out as a valuable reagent with demonstrable utility in various synthetic pathways. This article explores its chemical properties and applications from a chemist's viewpoint, emphasizing sourcing considerations for research and industrial production.

Chemical Profile and Reactivity of 4-Phenyl-2-butanol

4-Phenyl-2-butanol is a secondary alcohol with the molecular formula C10H14O. Its structure, featuring a phenyl group and a hydroxyl group on adjacent carbons of a four-carbon chain, imbues it with specific reactivity. A notable application highlighted in literature is its role as a reagent in the direct alkylation of amines using primary and secondary alcohols, often facilitated by biocatalytic hydrogen borrowing techniques. This process offers an efficient method for introducing alkyl groups onto amine substrates, a common transformation in the synthesis of pharmaceuticals, agrochemicals, and specialty materials.

The compound’s physical characteristics—typically a clear, colorless liquid—and its distinct floral-fruity odor profile are also significant. While primarily used as a synthetic intermediate, its aromatic qualities hint at potential applications in fragrance chemistry as well.

Sourcing High-Quality 4-Phenyl-2-butanol for Synthesis

Researchers and synthetic chemists looking to buy 4-Phenyl-2-butanol must prioritize sourcing from reputable chemical suppliers who can guarantee high purity (often ≥98%) and batch-to-batch consistency. The availability of detailed technical data sheets, safety data sheets (MSDS), and certificates of analysis (COA) is crucial for experimental planning and ensuring successful synthesis outcomes.

When procuring for laboratory use or pilot-scale synthesis, ordering from established chemical suppliers or directly from a manufacturer ensures authenticity and reliability. Companies often provide various quantities, from milligrams for initial screening to kilograms for scale-up operations. Understanding the price structure, which typically varies with quantity, is also important for budgeting research projects.

Beyond Alkylation: Other Synthetic Potentials

While amine alkylation is a key application, the hydroxyl group in 4-Phenyl-2-butanol offers other avenues for chemical modification. It can undergo typical alcohol reactions such as esterification, etherification, and oxidation, making it a versatile building block for creating a range of functionalized molecules. For example, its dehydration can lead to unsaturated compounds, further expanding its synthetic utility. The phenyl ring also provides a site for electrophilic aromatic substitution reactions.

For chemists aiming to explore novel synthetic routes or scale up existing processes, identifying a dependable manufacturer for 4-Phenyl-2-butanol is a strategic step. Access to this intermediate from reliable sources facilitates efficient research and development, contributing to breakthroughs in molecular design and synthesis.