For chemists, material scientists, and procurement specialists, understanding the fundamental properties of key chemical intermediates is crucial for successful application and sourcing. 4-Trifluoromethoxytoluene, identified by CAS number 706-27-4, is a valuable compound with a range of industrial applications. This article delves into its physical and chemical characteristics, as well as its significant roles in various sectors, and provides guidance on how to purchase this intermediate.

Understanding the Chemical Profile

Chemical Name: 4-Trifluoromethoxytoluene
CAS Number: 706-27-4
Synonyms: p-(Trifluoromethoxy)toluene, 4-(Trifluoromethoxy)benzene, 1-Methyl-4-(trifluoromethoxy)benzene
Molecular Formula: C8H7F3O
Molecular Weight: 176.14 g/mol

Physical Properties:

4-Trifluoromethoxytoluene is typically described as a clear, colorless liquid or a white solid with a low melting point. Key physical properties often cited include:

  • Appearance: Clear colorless liquid or white low melting solid
  • Boiling Point: Approximately 134-135 °C at 760 mmHg
  • Density: Around 1.179 g/mL at 25 °C
  • Flash Point: Approximately 87 °F (30.5 °C), classifying it as flammable.
  • Purity: Commonly available at 99% purity.

These properties highlight its handling requirements, particularly regarding its flammability and state at different temperatures.

Industrial Applications

The unique structure of 4-Trifluoromethoxytoluene, featuring the trifluoromethoxy group, makes it a valuable intermediate in several key industries:

  • Pharmaceutical Synthesis: It serves as a crucial building block for introducing the trifluoromethoxy moiety into drug molecules. This can enhance lipophilicity, metabolic stability, and receptor binding affinity, leading to improved drug efficacy. Researchers often buy this compound for creating novel APIs.
  • Electronic Chemicals: Its properties are beneficial in developing materials for advanced electronics, such as OLEDs, liquid crystal displays, and specialty polymers, contributing to thermal stability and specific optical or electrical characteristics.
  • Agrochemicals: Similar to pharmaceuticals, the trifluoromethoxy group can improve the efficacy and persistence of agrochemical compounds.
  • Fine Chemical Manufacturing: It is widely used as a versatile reagent and intermediate in various organic synthesis processes to create custom molecules for research and commercial purposes.

Procurement and Sourcing

When looking to buy 4-Trifluoromethoxytoluene, it is advisable to source from reputable manufacturers and suppliers, particularly those offering high purity (99%) material. Companies often seek manufacturers in China due to competitive pricing and extensive production capabilities. When requesting a quote, specify your required quantity, purity, and delivery specifications. Understanding the safety data (MSDS) and hazard symbols associated with the compound is also important for proper handling and storage. Reliable suppliers will readily provide this information and support your procurement needs.

4-Trifluoromethoxytoluene is a testament to the power of specialized chemical intermediates in driving innovation across multiple industries.