In the realm of toxicology and occupational health, precise reference standards are indispensable for accurate analysis and safety assessments. Acetonylacetone (CAS 110-13-4), also known as Hexane-2,5-dione, serves a critical function in this regard due to its established role as a neurotoxic metabolite of n-hexane and 2-hexanone. This article explores the significance of Acetonylacetone as a reference standard and guides professionals on where to buy high-purity material.

Acetonylacetone is the primary active metabolite responsible for the peripheral neurotoxicity associated with prolonged exposure to n-hexane, commonly found in industrial solvents and glues. Its γ-diketone structure is implicated in the cross-linking of neurofilament proteins, leading to axonal degeneration. Consequently, monitoring Acetonylacetone levels in biological samples, such as urine, is a crucial method for assessing occupational exposure to n-hexane. This analytical application underscores the need for certified, high-purity Acetonylacetone.

For researchers and safety officers requiring Acetonylacetone as a reference standard, sourcing from a reputable manufacturer is paramount. The accuracy of toxicological assays directly depends on the purity and consistency of the reference material. Therefore, when you seek to purchase Acetonylacetone for these sensitive applications, prioritize suppliers who provide detailed certificates of analysis (CoA) guaranteeing purity levels and assay results.

We, as a leading supplier in China, provide Acetonylacetone that meets the rigorous demands of analytical and toxicological laboratories. Our commitment to quality ensures that our Acetonylacetone is suitable for use as a standard in gas chromatography (GC) or liquid chromatography-mass spectrometry (LC-MS) methods for biological monitoring. Understanding the specific needs of toxicological research allows us to offer precisely what these critical applications require.

Beyond its use as a standard, Acetonylacetone is also employed in chemical synthesis, contributing to its overall market relevance. However, for toxicological applications, the focus remains on its well-defined identity and purity. When evaluating potential suppliers, consider:

  • Analytical Grade Purity: Ensure the product is specifically graded for analytical or reference standard use.
  • Traceability: Look for manufacturers with robust quality management systems that ensure batch traceability.
  • Packaging and Storage: Proper packaging and recommended storage conditions are vital to maintain the integrity of the reference standard.

By understanding the critical role of Acetonylacetone in neurotoxicity assessment and by partnering with reliable suppliers who prioritize purity, laboratories can ensure the accuracy and validity of their research and safety monitoring protocols. If your work requires this essential reference material, engage with a trusted manufacturer to secure your supply.