The chemical industry constantly seeks versatile and efficient reagents to push the boundaries of organic synthesis. tert-Butyl Nitrite (CAS 540-80-7), a colorless transparent liquid, stands out as a crucial compound for many advanced chemical transformations. As a leading supplier of fine chemicals, understanding its application spectrum is vital for R&D scientists and product developers.

What is tert-Butyl Nitrite?

tert-Butyl Nitrite is the tert-butyl ester of nitrous acid. Its molecular formula is C4H9NO2, and it is recognized for being an efficient source of the nitric oxide (NO) radical. This property, combined with its reactivity, makes it a valuable tool in synthetic organic chemistry. When searching for a 'tert-Butyl Nitrite manufacturer', it's important to note its primary functions.

Key Applications in Organic Synthesis

1. Nitrosation Reactions: One of the most prominent uses of tert-Butyl Nitrite is as a nitrosating agent. It readily reacts with various nucleophiles to form nitroso compounds. This is particularly useful for the synthesis of N-nitroso amides from secondary amides. Researchers often buy tert-Butyl Nitrite for these specific transformations due to its clean reactivity and the relative ease of handling compared to other nitrosating agents. The mechanism often involves the generation of the nitrosonium ion (NO+).

2. Organic Intermediate: tert-Butyl Nitrite serves as a critical intermediate in the synthesis of more complex molecules. Its involvement in drug synthesis pathways is well-documented, where it facilitates specific functional group introductions or modifications. For example, it can be used in the synthesis of certain vasopressin analogues, highlighting its importance in pharmaceutical research and development. If you are looking for a reliable 'tert-Butyl Nitrite supplier' for your pharmaceutical intermediates, ensuring high purity is key.

3. Radical Chemistry: Under photolytic conditions (near-UV irradiation), tert-Butyl Nitrite can cleave to generate tert-butoxy radicals and nitrogen monoxide (NO). This characteristic allows it to be used in reactions that require controlled radical generation, opening up possibilities in polymerization or selective functionalization of organic molecules.

4. Diazotization: While less common than its nitrosation role, tert-Butyl Nitrite can also be employed in diazotization reactions under specific conditions, particularly with amines, leading to diazonium salts which are themselves versatile synthetic intermediates.

Sourcing tert-Butyl Nitrite from China

For businesses looking to purchase tert-Butyl Nitrite, sourcing from reputable manufacturers in China offers a compelling combination of quality and cost-effectiveness. When you 'buy tert-Butyl Nitrite' from a well-established Chinese supplier, you can expect stringent quality control, with purities often exceeding 99%. This ensures that the reagent performs optimally in demanding organic synthesis applications. Always confirm the CAS number (540-80-7) and inquire about the tert-Butyl Nitrite price for bulk orders to maximize your procurement budget.

In summary, tert-Butyl Nitrite is a foundational reagent in modern organic synthesis. Its versatility in nitrosation, its role as a drug synthesis intermediate, and its utility in radical chemistry make it an indispensable compound. Partnering with a reliable tert-Butyl Nitrite manufacturer ensures access to a high-quality product essential for innovation in the chemical sciences.