Benzonitrile derivatives form a significant class of organic compounds, valued for the inherent reactivity of the nitrile group (-CN) and the versatility of the aromatic ring, which can be further functionalized. Among these, 3-Bromo-5-methylbenzonitrile (CAS 124289-21-0) is a particularly useful compound that bridges the gap between fundamental research and applied chemistry, finding utility in pharmaceuticals, agrochemicals, and materials science.

The Versatility of Benzonitrile Structures

The nitrile group is a polar functional group that can undergo a variety of transformations. It can be hydrolyzed to carboxylic acids or amides, reduced to amines, or participate in cycloaddition reactions. The aromatic ring provides a stable scaffold that can be substituted at various positions, allowing for the fine-tuning of molecular properties. The specific substitution pattern in 3-Bromo-5-methylbenzonitrile—a bromine atom at the 3-position and a methyl group at the 5-position relative to the nitrile—creates a unique reactivity profile.

3-Bromo-5-methylbenzonitrile: Key Features and Uses

As a chemical intermediate, 3-Bromo-5-methylbenzonitrile (C8H6BrN, MW 196.04) is prized for several attributes:

  • Bromine as a Leaving Group: The bromine atom is highly amenable to palladium-catalyzed cross-coupling reactions. This makes the molecule a potent substrate for building more complex organic frameworks, essential for drug discovery and advanced material synthesis.
  • Methyl Group Influence: The methyl group can influence solubility, steric hindrance, and electronic properties of the molecule and subsequent derivatives.
  • Nitrile Functionality: The nitrile group can be further modified, offering a pathway to amines, carboxylic acids, or other nitrogen-containing heterocycles.

These characteristics make it valuable for synthesis chemists who need to create specific molecular architectures. Whether you are looking to buy 3-Bromo-5-methylbenzonitrile for pharmaceutical research, agrochemical development, or novel material creation, its structure offers a robust starting point.

Sourcing High-Quality Intermediates

For professionals in research and development, securing a reliable supply of high-purity chemical intermediates is paramount. When seeking to purchase 3-Bromo-5-methylbenzonitrile, it is advisable to work with established chemical suppliers and manufacturers. Companies often list this compound with specifications such as 97% purity and provide supporting documentation like Certificates of Analysis (CoA). Many leading manufacturers, particularly those based in China, are equipped to supply this intermediate in quantities ranging from laboratory-scale grams to bulk industrial kilograms, ensuring availability for both pilot studies and large-scale production.

The Role of Suppliers and Manufacturers

A trustworthy 3-Bromo-5-methylbenzonitrile manufacturer or supplier will not only provide a high-quality product but also offer comprehensive technical support and transparent pricing. Many are willing to provide free samples to allow researchers to assess the compound's suitability. When you need to find a 3-Bromo-5-methylbenzonitrile supplier, consider factors like their catalog diversity, responsiveness, and established quality control measures. Companies that specialize in custom synthesis can also be valuable partners for specific project needs.

In summary, 3-Bromo-5-methylbenzonitrile is a potent and versatile benzonitrile derivative that empowers chemists across various disciplines. Its ability to participate in crucial synthetic transformations makes it an indispensable tool for innovation. By understanding its properties and engaging with reliable suppliers, researchers can effectively leverage this compound for their advanced chemical projects.