While 2-Chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) is widely recognized for its efficacy in peptide synthesis, its utility extends far beyond this foundational application. As a versatile chemical intermediate, CDMT plays a crucial role in various advanced organic transformations, making it an indispensable reagent for researchers and manufacturers across diverse scientific disciplines. From our position as a leading manufacturer in China, we are pleased to showcase the broader applications of this powerful coupling reagent.

CDMT in the Synthesis of Specialized Amides and Esters

CDMT's ability to efficiently activate carboxylic acids makes it ideal for synthesizing specific types of amides and esters that are critical in various fields:

  • Weinreb Amides: CDMT is highly effective in the synthesis of Weinreb amides. These intermediates are valuable in organic synthesis as they can be readily converted into ketones or tertiary alcohols under mild conditions, avoiding over-addition issues common with other amide derivatives. This makes them particularly useful in complex drug molecule synthesis.
  • Hydroxamates: The reagent also facilitates the formation of hydroxamates, which are important functional groups found in various biologically active compounds and are used as enzyme inhibitors.
  • Lipid Chemistry and Membrane Studies: Research has shown CDMT's involvement in chemical formation of ceramides through membrane fusion. Ceramides are vital components of cell membranes, and understanding their synthesis and function is key in lipid research and therapeutic development.

Other Notable Applications of CDMT

  • Lactamization: CDMT can be used for the intramolecular cyclization of ω-amino acids to form lactams, a common structural motif in many pharmaceuticals and natural products.
  • Activation of Carboxylic Acids for Other Transformations: The activated species formed by CDMT can be utilized in various other reactions beyond simple amide or ester formation, showcasing its broad synthetic utility.

Why Choose Our CDMT?

For those looking to buy 2-Chloro-4,6-dimethoxy-1,3,5-triazine for these diverse applications, partnering with a reliable supplier in China is essential. We guarantee high purity (≥98% HPLC) and consistency, ensuring that your synthesis outcomes are reproducible and efficient, whether you are developing novel pharmaceuticals or advancing fundamental research. We are a premier manufacturer and supplier of CDMT.

If you are interested in the price of CDMT or wish to purchase this versatile reagent for your research or industrial needs, contact us today. We are committed to providing the chemical building blocks that drive innovation.