Understanding the precise chemical profile of an intermediate is fundamental to its successful application in organic synthesis. 1-Bromo-4-chloro-2-methoxybenzene, more commonly known as 2-Bromo-5-chloroanisole (CAS: 174913-09-8), is a compound whose specific structure and reactivity make it invaluable. This article provides an in-depth look at its chemical and physical properties and explores its role as a critical organic synthesis intermediate. NINGBO INNO PHARMCHEM CO.,LTD. is a leading manufacturer of fine chemicals, including this essential compound.

The molecular formula for 2-Bromo-5-chloroanisole is C7H6BrClO, with a molecular weight of 221.48 g/mol. Its appearance is typically described as a white to yellow solid, indicating its crystalline nature at room temperature. Key physical properties include a density of 1.564 g/cm³ and a boiling point of 236.6 °C, which are important considerations for reaction design and process optimization. The compound’s refractive index is noted at 1.5875. The presence of a methoxy group (-OCH3) on the anisole core, along with the bromine and chlorine substituents, dictates its chemical behavior. These functional groups influence its electron density distribution, making specific positions on the aromatic ring susceptible to electrophilic or nucleophilic attack, and enabling participation in a variety of catalytic cross-coupling reactions.

The reactivity of 2-Bromo-5-chloroanisole is a major reason for its widespread use as an organic synthesis building block. The carbon-bromine bond is particularly amenable to reactions like Suzuki-Miyaura coupling, Stille coupling, and Ullmann coupling, allowing for the facile formation of new carbon-carbon bonds. The chlorine atom also offers potential for further functionalization, although it is generally less reactive than the bromine atom under typical coupling conditions. This differential reactivity can be exploited to achieve selective modifications. As a reliable supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. ensures that this intermediate is produced to high purity standards (≥98.0%), which is critical for reproducible and efficient synthetic outcomes in both academic research and industrial manufacturing.

The applications of 1-Bromo-4-chloro-2-methoxybenzene are diverse, spanning the synthesis of pharmaceuticals, agrochemicals, and materials for liquid crystals and electronics. Its role as an intermediate underscores the importance of understanding detailed chemical information when selecting raw materials. For companies looking to purchase 2-Bromo-5-chloroanisole, NINGBO INNO PHARMCHEM CO.,LTD. offers a dependable source, backed by robust manufacturing expertise. The compound’s well-defined chemical profile makes it a cornerstone for chemists developing innovative molecular structures.