The Chemical Profile of 3-Fluoro-4-methylbenzonitrile: Properties and Synthesis Explained
Understanding the fundamental chemical profile of an intermediate like 3-Fluoro-4-methylbenzonitrile is key to unlocking its full potential in synthesis and application. This compound, with the CAS number 170572-49-3 and molecular formula C8H6FN, is a derivative of benzonitrile, distinguished by the presence of a fluorine atom at the meta position and a methyl group at the para position relative to the nitrile functionality.
The physical and chemical properties of 3-Fluoro-4-methylbenzonitrile are critical for its handling and use. It typically presents as an off-white to beige crystalline solid, with a melting point generally falling between 48-50°C. Its boiling point is around 204°C, and it has a flash point of approximately 90.3°C. These characteristics indicate a stable compound that is manageable under standard laboratory and industrial conditions. Solubility is generally good in common organic solvents, which is advantageous for reaction processes.
The synthesis of 3-Fluoro-4-methylbenzonitrile can be achieved through various routes. One common approach involves the preparation from precursors like methyl 2-fluoro-4-cyanophenylacetate, often utilizing dehydrating agents such as calcium chloride at elevated temperatures. Another method might involve diazotization reactions starting from the corresponding aniline derivative, followed by a cyanation step. NINGBO INNO PHARMCHEM CO.,LTD, as a specialist in fine chemical manufacturing, focuses on optimizing these synthesis pathways to ensure high purity and yield, offering the product at competitive prices.
The structural features of 3-Fluoro-4-methylbenzonitrile are also noteworthy. The fluorine atom's electronegativity significantly influences the electron distribution within the molecule, impacting its reactivity and intermolecular interactions. The methyl group contributes electron density via hyperconjugation. This interplay of substituents makes it a valuable starting material for synthesizing a wide range of complex organic molecules, including those used in pharmaceuticals and agrochemicals. Researchers looking to buy 3-Fluoro-4-methylbenzonitrile will find that its well-defined chemical properties and synthetic accessibility make it a cornerstone for numerous chemical endeavors.
The physical and chemical properties of 3-Fluoro-4-methylbenzonitrile are critical for its handling and use. It typically presents as an off-white to beige crystalline solid, with a melting point generally falling between 48-50°C. Its boiling point is around 204°C, and it has a flash point of approximately 90.3°C. These characteristics indicate a stable compound that is manageable under standard laboratory and industrial conditions. Solubility is generally good in common organic solvents, which is advantageous for reaction processes.
The synthesis of 3-Fluoro-4-methylbenzonitrile can be achieved through various routes. One common approach involves the preparation from precursors like methyl 2-fluoro-4-cyanophenylacetate, often utilizing dehydrating agents such as calcium chloride at elevated temperatures. Another method might involve diazotization reactions starting from the corresponding aniline derivative, followed by a cyanation step. NINGBO INNO PHARMCHEM CO.,LTD, as a specialist in fine chemical manufacturing, focuses on optimizing these synthesis pathways to ensure high purity and yield, offering the product at competitive prices.
The structural features of 3-Fluoro-4-methylbenzonitrile are also noteworthy. The fluorine atom's electronegativity significantly influences the electron distribution within the molecule, impacting its reactivity and intermolecular interactions. The methyl group contributes electron density via hyperconjugation. This interplay of substituents makes it a valuable starting material for synthesizing a wide range of complex organic molecules, including those used in pharmaceuticals and agrochemicals. Researchers looking to buy 3-Fluoro-4-methylbenzonitrile will find that its well-defined chemical properties and synthetic accessibility make it a cornerstone for numerous chemical endeavors.
Perspectives & Insights
Silicon Analyst 88
“It typically presents as an off-white to beige crystalline solid, with a melting point generally falling between 48-50°C.”
Quantum Seeker Pro
“These characteristics indicate a stable compound that is manageable under standard laboratory and industrial conditions.”
Bio Reader 7
“Solubility is generally good in common organic solvents, which is advantageous for reaction processes.”