For chemists, researchers, and procurement specialists, a thorough understanding of a chemical’s profile is crucial for safe and effective utilization. 4-Nitrophenylhydrazine Hydrochloride (CAS 636-99-7) is a significant compound in organic chemistry, and grasping its properties, applications, and safety data is paramount. This guide aims to provide essential information for those looking to buy or work with this chemical.

Chemical Identity and Properties

4-Nitrophenylhydrazine Hydrochloride, identified by CAS number 636-99-7, is a derivative of phenylhydrazine. Its chemical formula is C6H8ClN3O2, with a molecular weight of approximately 189.6 g/mol. It typically appears as a brown to reddish-brown crystalline powder. Key physical properties include a melting point in the range of 205-207°C. The presence of the nitro group (NO2) and the hydrazine moiety (NHNH2) makes it a reactive compound, valuable for various synthetic transformations.

Primary Applications and Uses

The utility of 4-Nitrophenylhydrazine Hydrochloride spans several areas:

  • Organic Synthesis: It serves as a vital building block and reagent for synthesizing heterocyclic compounds, such as pyrazoles and indoles, which are core structures in many biologically active molecules.
  • Pharmaceutical Intermediates: Researchers utilize it in the development of potential pharmaceutical agents, investigating its role in creating new drugs.
  • Analytical Reagent: Historically, phenylhydrazine derivatives have been used in analytical chemistry, for example, in the characterization of carbonyl compounds.
  • Research & Development: Its reactivity makes it a subject of interest in various academic and industrial research projects exploring new chemical reactions and materials.

Companies looking to buy this chemical often do so for its role as a precursor or reactant in multi-step synthesis processes.

Safety, Handling, and Storage

Like many hydrazine derivatives and nitroaromatic compounds, 4-Nitrophenylhydrazine Hydrochloride requires careful handling. According to GHS classifications, it can be harmful if swallowed (H302), cause skin irritation (H315), and serious eye irritation (H319). Therefore, standard laboratory safety precautions are essential:

  • Personal Protective Equipment (PPE): Always wear appropriate gloves, eye protection (safety glasses or goggles), and lab coats.
  • Ventilation: Handle in a well-ventilated area, preferably a fume hood, to minimize inhalation exposure.
  • Storage: Store in a cool, dry place, away from incompatible materials. Some sources suggest storage under inert gas at 2-8°C for optimal stability.
  • Incompatibilities: Avoid contact with strong oxidizing agents.

Procurement managers should ensure that their teams are well-trained in handling such chemicals and that Safety Data Sheets (SDS) are readily available and reviewed.

Sourcing and Procurement Considerations

When procuring 4-Nitrophenylhydrazine Hydrochloride (CAS 636-99-7), it is vital to partner with reliable manufacturers and suppliers. Reputable chemical companies will provide high-purity material with detailed specifications and safety information. Obtaining quotes from established suppliers, particularly those in China known for their fine chemical production capabilities, can ensure both quality and cost-effectiveness for your research or industrial needs.

By understanding the chemical profile and safety requirements of 4-Nitrophenylhydrazine Hydrochloride, you can ensure its effective and safe use in your laboratory or manufacturing processes.