For any chemist engaged in synthesis, a deep understanding of the chemical properties of their starting materials is fundamental to success. 4-Fluorobenzophenone (CAS 345-83-5) is a compound whose specific characteristics make it an exceptionally valuable intermediate in a wide array of chemical processes. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer and supplier, provides this crucial building block to researchers and industrial chemists.

The chemical structure of 4-Fluorobenzophenone, C13H9FO, is key to its utility. It is characterized by a carbonyl group (C=O) bridging a phenyl ring and a 4-fluorophenyl ring. This arrangement results in a molecule with a molecular weight of approximately 200.21 g/mol. The carbonyl group is electrophilic, making it susceptible to nucleophilic attack, a cornerstone of many organic reactions. This reactivity is foundational for its use in various synthesis pathways.

The presence of the fluorine atom on the phenyl ring is not merely an addition; it significantly influences the molecule's electronic properties and reactivity. Fluorine is highly electronegative, drawing electron density away from the phenyl ring. This electron-withdrawing effect can modulate the reactivity of the carbonyl group and also impact the behavior of the aromatic ring itself in electrophilic aromatic substitution reactions, though such reactions are less common for benzophenones compared to additions at the carbonyl.

One of the most significant aspects for chemists looking to buy 4-Fluorobenzophenone is its role as a precursor. It readily participates in reactions such as:

  • Grignard Reactions: Alkyllithium or Grignard reagents can add to the carbonyl carbon, forming tertiary alcohols.
  • Reduction: The carbonyl group can be reduced to a secondary alcohol using agents like sodium borohydride.
  • Wittig Reactions: Reaction with phosphorus ylides can lead to the formation of substituted alkenes.
  • Photochemistry: Benzophenones are known for their photochemical properties and can act as photosensitizers, although this is a more specialized application.

For pharmaceutical applications, the fluorine atom in 4-Fluorobenzophenone is particularly advantageous. It can increase lipophilicity, improve metabolic stability by blocking oxidation sites, and subtly alter binding affinities to biological targets. Therefore, when scientists are developing new drug candidates, sourcing a reliable supplier of high-purity 4-Fluorobenzophenone (typically 97% min.) is a strategic priority.

NINGBO INNO PHARMCHEM CO.,LTD. understands the importance of consistent quality for these sensitive applications. As a manufacturer, we ensure that our 4-Fluorobenzophenone adheres to strict specifications. We invite procurement managers and R&D scientists to inquire about our product, obtain quotes, and request samples to verify its suitability for their synthesis needs. Our commitment is to provide the chemical foundations for your next innovation.